Journal of Rheumatic Diseases

Table. 1.

Baseline clinical and laboratory characteristics in iRPF patients according to the short-term outcomes of hydronephrosis

Characteristics All patients (n=18) With improvement (n=8) Without improvement (n=10) p-value
Clinical characteristics
Sex, male 14 (77.8) 5 (62.5) 9 (90) 0.275
Age (yr) 62 (54∼65) 62 (57∼62) 61 (52∼67) 0.897
Symptoms 16 (88.9) 7 (87.5) 9 (90) 1.000
Flank pain 7 (38.9) 5 (62.5) 2 (20) 0.145
Abdominal pain 6 (33.3) 1 (12.5) 5 (50) 0.152
Urinary frequency 2 (11.1) 1 (12.5) 1 (10) 1.000
Leg edema 4 (22.2) 1 (12.5) 3 (30) 0.588
Smoker 11 (61.1) 5 (62.5) 6 (60) 1.000
Diabetes mellitus 2 (11.1) 0 (0) 2 (20) 0.477
Hypertension 10 (55.6) 4 (50) 6 (60) 1.000
Hydronephrosis
Right 17 (94.4) 7 (87.5) 10 (100) 0.444
Left 15 (83.3) 7 (87.5) 8 (80) 1.000
Bilateral 14 (77.8) 6 (75) 8 (80) 1.000
Distribution of involvement
Ureter only 6 (33.3) 1 (12.5) 5 (50) 0.152
Abdominal aorta 10 (55.6) 7 (87.5) 3 (30) 0.025
Peritoneum 2 (11.1) 0 (0) 2 (20) 0.477
Laboratory findings
Serum creatinine (mg/dL) 1.07 (0.82∼2.54) 0.98 (0.83∼3.56) 1.12 (0.72∼2.54) 1.000
GFR (mL/min/1.73 m2) 76 (23∼86) 78 (18∼82) 72 (26∼95) 0.573
WBC (×103/mm3) 7.25 (5.40∼8.51) 6.20 (5.13∼7.33) 7.85 (6.53∼8.61) 0.146
Hemoglobin (g/dL) 11.9 (10.7∼13.6) 12.4 (11.7∼13.7) 11.1 (10.2∼13.1) 0.173
ESR (mm/h) 52 (21∼64) 56 (36∼61) 32 (16∼75) 0.460
CRP (mg/dL) 0.63 (0.23∼5.11) 0.66 (0.22∼3.05) 0.58 (0.23∼10.31) 0.965
Serum IgG subclasses levels (mg/dL)
IgG1 844 (734∼1,001) 902 (798∼1,027) 806 (669∼951) 0.408
IgG2 559 (497∼757) 559 (407∼639) 656 (524∼960) 0.173
IgG3 66 (42∼86) 61 (28∼91) 66 (45∼87) 0.633
IgG4 68 (39∼134) 107 (55∼158) 55 (36∼134) 0.408
IgG4>UNL, n (%) 4 (22.2) 2 (25.0) 2 (20) 1.000
Serum IgG subclasses ratios
IgG4/IgG1 0.08 (0.06∼0.13) 0.10 (0.06∼0.20) 0.07 (0.05∼0.11) 0.315
IgG4/IgG2 0.13 (0.08∼0.23) 0.19 (0.13∼0.28) 0.09 (0.06∼0.15) 0.027
IgG4/IgG3 1.09 (0.69∼2.47) 2.06 (1.24∼2.51) 0.90 (0.51∼1.98) 0.122
IgG4/IgG3>1 10 (55.6) 7 (87.5) 3 (30) 0.025

Data are expressed as number (%) or median (interquartile range). iRPF: idiopathic retroperitoneal fibrosis, GFR: glomerular filtration rate, WBC: white blood cell, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, UNL: upper normal limit.

J Rheum Dis 2021;28:38~44 https://doi.org/10.4078/jrd.2021.28.1.38
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