Journal of Rheumatic Diseases

Table. 4.

Interactions with baseline characteristics and spinal radiographic progression with generalized estimating equations model (n=101)

Variable Univariate analysis Multivariable analysis


β (95% CI) p-value β (95% CI) p-value
Time 1.68 (1.04∼2.32) <0.001 −1.22 (−4.71∼2.28) 0.494
Time*female −1.44 (−2.18∼−0.70) <0.001 −1.40 (−2.27∼−0.54) 0.001
Time*current smoker −0.19 (−0.18∼1.10) 0.772
Time*uveitis −0.22 (−1.52∼1.08) 0.738
Time*enthesitis −1.04 (−1.87∼−0.22) 0.013 0.29 (−0.43∼1.01) 0.430
Time*peripheral arthritis −1.24 (−2.33∼−0.16) 0.025 −0.37 (−1.29∼0.56) 0.438
Time*hip arthritis −0.23 (−1.65∼1.19) 0.749
Time*anti TNF use −0.26 (−2.42∼1.90) 0.811
Time*leptin/100 −0.01 (−0.02∼0.01) 0.472
Time*Dkk1/100 −0.11 (−0.03∼−2.69) 0.007 −0.11 (−0.13∼−0.06) <0.001
Time*estrogen −0.01 (−0.03∼0.01) 0.313
Time*age at symptom onset 0.07 (0.03∼0.12) 0.002 0.03 (−0.01∼0.07) 0.098
Time*initial ESR 0.01 (−0.01∼0.02) 0.421
Time*initial CRP 0.23 (0.08∼0.39) 0.003 0.11 (−0.01∼0.22) 0.059
Time*BMI 0.20 (0.05∼0.36) 0.011 0.12 (0.01∼0.25) 0.047
Time*initial mSASSS 0.04 (−0.02∼0.09) 0.186 0.00 (−0.01∼0.02) 0.798

TNF: tumor necrosis factor, Dkk1: dickkopf-1, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, BMI: body mass index, mSASSS: modified Stoke Ankylosing Spondylitis Spine Score, CI: confidence interval.

J Rheum Dis 2021;28:76~84 https://doi.org/10.4078/jrd.2021.28.2.76
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