Journal of Rheumatic Diseases

Table. 1.

Instrumental SNPs associated with gut microbiome and OA GWASs

Instrumental SNP Gene Effect allele Exposure (gut microbiome) Outcome (OA)


Beta SE p-value Beta SE p-value
rs1009634 AKAP3 G −1.310 0.226 7.00E-09 0.030 0.055 0.561
rs10928827 HS6ST1 G −0.230 0.039 4.00E-09 −0.010 0.021 0.600
rs11626933 C14orf102 G −0.240 0.043 2.00E-08 0.010 0.025 0.720
rs11724031 SHROOM3 G −0.970 0.152 2.00E-10 −0.077 0.035 0.036
rs11877825 NAPG G −0.270 0.041 3.00E-11 −0.010 0.025 0.756
rs11915634 CNTN6 T −1.300 0.206 3.00E-10 0.062 0.048 0.237
rs1230666 MAGI3 A −4.583 1.004 5.00E-06 0.010 0.030 0.841
rs12442649 TMCO5A G −1.490 0.271 4.00E-08 0.073 0.038 0.062
rs13096731 FLNB A −0.430 0.078 3.00E-08 0.020 0.022 0.352
rs17085775 C9orf71 C −1.030 0.184 2.00E-08 0.041 0.034 0.288
rs17661843 ABCA13 T −1.400 0.185 4.00E-14 −0.020 0.033 0.606
rs2071199 HNF4A-AS1 T −0.320 0.056 1.00E-08 0.010 0.031 0.857
rs2294239 ZNRF3 G −4.676 1.001 3.00E-06 0.010 0.023 0.802
rs2318350 COL22A1 T −1.150 0.195 4.00E-09 0.051 0.040 0.210
rs249733 SPRY4 T −0.650 0.105 5.00E-10 −0.030 0.021 0.174
rs35275482 BNIP2 C −0.540 0.082 4.00E-11 0.000 0.028 0.883
rs4621152 AC007557.1 C −0.290 0.051 1.00E-08 0.041 0.024 0.099
rs4669413 RP11-521D12.1 T −0.180 0.031 1.00E-08 0.030 0.022 0.128
rs479105 PRMT8 T −0.220 0.038 1.00E-08 −0.020 0.021 0.351
rs56006724 C2orf83 A −0.880 0.142 6.00E-10 0.000 0.026 0.866
rs59042687 LINC00879 T −0.230 0.040 6.00E-09 0.000 0.020 0.962
rs597205 C1orf183 T −0.620 0.107 8.00E-09 −0.039 0.039 0.344
rs62295801 LINC01192 G −0.270 0.043 5.00E-10 0.010 0.023 0.648
rs75036654 LINC01137 C −1.390 0.224 5.00E-10 0.000 0.043 0.910
rs9291879 CD180 C −0.580 0.099 4.00E-09 −0.062 0.030 0.062
rs9300430 RAP2A C −0.610 0.100 1.00E-09 0.000 0.041 0.937
rs9323326 SLC35F4 A −0.210 0.034 9.00E-10 −0.020 0.024 0.272
rs9831278 LINC00973 C −1.160 0.209 3.00E-08 −0.068 0.055 0.215
rs986417 SIX6 C −1.400 0.236 3.00E-09 −0.058 0.039 0.132

SNP: single nucleotide polymorphism, GWAS: genome-wide association study, Beta: beta coefficient, SE: standard error, OA: osteoarthritis.

J Rheum Dis 2021;28:94~100 https://doi.org/10.4078/jrd.2021.28.2.94
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