J Rheum Dis 2016; 23(3): 148-153  
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
Semun Seong1,2, Jung Ha Kim1, Nacksung Kim1,2
Departments of 1Pharmacology and 2Biomedical Sciences, Chonnam National University Medical School, Gwangju, Korea
Correspondence to: Nacksung Kim, Department of Pharmacology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Korea. E-mail:nacksung@jnu.ac.kr
Received: June 2, 2016; Revised: June 7, 2016; Accepted: June 11, 2016; Published online: June 30, 2016.
© Korean College of Rheumatology. All rights reserved.

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In general, bone homeostasis is maintained through the balance between bone formation and resorption. Disruption in this balance results in bone-related diseases such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Often, enhanced osteoclastogenesis is followed by accelerated bone resorption that is induced by pro-inflammatory cytokines in osteoporosis or rheumatoid arthritis, and leads to bone destruction. In this review study, factors involved in osteoclast differentiation and function are discussed, and how the prevention of such factors is effective in ameliorating bone loss in osteoporosis or rheumatoid arthritis. (J Rheum Dis 2016;23:148-153)
Keywords: Bone and bones, Osteoclasts, Rheumatoid arthritis, Cytokines

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