J Rheum Dis 2017; 24(3): 157-160  
A Case of Refractory Oral Aphthous Ulcer Successfully Treated with Adalimumab
Jinyeong Kim1, Myung-jin Song1, Hye-Jin Jeong2, Soo-Kyung Cho1,3, Yoon-Kyoung Sung1,3
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, 2Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea
Correspondence to: Yoon-Kyoung Sung, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
Received: June 15, 2016; Revised: August 30, 2016; Accepted: September 20, 2016; Published online: June 30, 2017.
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Oral aphthous ulcer is a common lesion characterized by loss of dermal tissue of various shapes in many diseases. It is not serious, but may affect quality of life through pain and discomfort. In many cases, it heals spontaneously without treatment or with topical agents such as antiseptics, analgesics and corticosteroid in a few days. However, rarely, there are a few cases of aphthous ulcer that remain refractory despite appropriate treatment. Tumor necrosis factor-α inhibitors have recently been used in treatment of severe mucosal ulcer in Behçet’s disease. Herein, we report a patient suffering from refractory oral aphthous ulcers that were resistant to topical and systemic agents, but were successfully treated with adalimumab.
Keywords: Oral ulcer, Aphthous stomatitis, Tumor necrosis factor-alpha inhibitor, Adalimumab

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