J Rheum Dis 2018; 25(4): 302-305  
Successful Treatment of Refractory Cutaneous Polyarteritis Nodosa with Adalimumab
Eunyoung Ahn, Min Wook So
Division of Rheumatology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
Correspondence to: Min Wook So http://orcid.org/0000-0001-5027-0410
Division of Rheumatology, Department of Internal Medicine, Pusan National University Yangsan Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea. E-mail:thalsdnrso@naver.com
Received: May 5, 2018; Revised: May 17, 2018; Accepted: May 24, 2018; Published online: October 1, 2018.
© Korean College of Rheumatology. All rights reserved.

This is a open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of the medium and small-sized arteries. The condition is limited to the skin and there is a lack of visceral involvement. Treatment with systemic glucocorticoids alone or in combination with azathioprine, methotrexate or cyclophosphamide, depending on the disease severity, has been shown to be effective. This paper reports the clinical case of a 53-year-old female patient with CPAN refractory to treatment with high dose glucocorticoid, methotrexate, azathioprine, and cyclophosphamide, who was treated successfully with anti-tumor necrosis factor-α therapy (adalimumab).
Keywords: Polyarteritis nodosa, Skin, Tumor necrosis factor, Adalimumab


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