J Rheum Dis 2019; 26(3): 206-210  
Follicular Bronchiolitis Mimicking Lung Cancer in a Patient with Primary Sjögren's Syndrome
Seunghwan Shin1, You-Jung Ha1,4, Eun Ha Kang1,4, Yeong Wook Song2,3,4, Yun Jong Lee1,4
1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 2Department of Internal Medicine, Seoul National University Hospital, Seoul, 3WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, Seoul National University College of Medicine, Seoul, 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Correspondence to: Yun Jong Lee http://orcid.org/0000-0001-7615-8611
Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea. E-mail:yn35@snu.ac.kr
Received: November 30, 2018; Revised: December 31, 2018; Accepted: January 22, 2019; Published online: July 1, 2019.
© Korean College of Rheumatology. All rights reserved.

This is a open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Follicular bronchiolitis (FB) is an uncommon pulmonary lymphoproliferative disorder that is characterized by the presence of peribronchiolar hyperplastic lymphoid follicles with reactive germinal centers. FB could be associated with systemic illnesses including immunodeficiency, infection, and autoimmune diseases. In Korea, a single case of FB with rheumatoid arthritis was recently described but there has been no report on FB associated with other rheumatic diseases. Herein, we describe the first case of FB presenting nodular ground-glass opacities (GGO), which mimicked lung cancer, in patients with primary Sjögren's syndrome (SS). The differential diagnosis of nodular GGO lesions should include FB although it is a rare manifestation in SS patients.
Keywords: Sjögren's syndrome, Lung neoplasms, Lung diseases, interstitial, Bronchiolitis


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