J Rheum Dis 2020; 27(2): 100-109  
Comparison of Clinical, Angiographic Features and Outcome in Takayasu’s Arteritis and Behçet’s Disease With Arterial Involvement
Su Jin Choi, M.D.1, Hyun Jung Koo, M.D., Ph.D.2, Dong Hyun Yang, M.D., Ph.D.2, Joon-Won Kang, M.D., Ph.D.2, Ji Seon Oh, M.D., Ph.D.1, Seokchan Hong, M.D., Ph.D.1, Yong-Gil Kim, M.D., Ph.D.1, Bin Yoo, M.D., Ph.D.1, Chang-Keun Lee, M.D., Ph.D.1
1Division of Rheumatology, Department of Internal Medicine, 2Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to: Chang-Keun Lee http://orcid.org/0000-0003-3653-7515
Division of Rheumatology, Department of Internal Medicine, Asan Medical center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.
E-mail:cklee@amc.seoul.kr
Received: December 3, 2019; Revised: February 3, 2020; Accepted: February 21, 2020; Published online: April 1, 2020.
© Korean College of Rheumatology. All rights reserved.

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Abstract
Objective. Takayasu’s arteritis (TAK) is a vasculitis that primarily involves the aorta and its branches. In Behçet’s disease (BD), systemic vasculitis is one of major manifestations. We aimed to compare clinical and angiographic features and outcome between TAK and BD with arterial involvement. Methods. We retrospectively reviewed medical records of 206 TAK patients and 50 BD patients between 1995 and 2015. Angiographic lesions were evaluated via computed tomography, magnetic resonance imaging, and/or conventional angiography. Results. Fever (30% vs. 9.2%, p <0.001) and arthralgia (36% vs. 7.3%, p<0.001) were more common in BD. C-reactive protein was higher in BD compared with TAK (5.85 mg/dL vs. 2.08 mg/dL, p <0.001). Stenosis (89.8% vs. 60%, p<0.001) and occlusion (65.5% vs. 32%, p <0.001) were more observed in TAK. In contrast, aneurysm was common in BD (62% vs. 20.9%, p<0.001). The carotid artery (73.3% vs. 30%, p<0.001), subclavian artery (71.4% vs. 16%, p<0.001), descending aorta (35% vs. 12%, p=0.002), renal artery (23.8% vs. 10%, p=0.032), superior mesenteric artery (18.4% vs. 4%, p=0.012), and brachiocephalic trunk (13.6% vs. 2%, p=0.020) were more commonly involved in TAK, whereas the femoral artery (10% vs. 2.4%, p=0.027) was more frequently involved in BD. During follow-up, arterial dissection (10% vs. 1.9%, p=0.016), rupture (12% vs. 0.5%, p<0.001), and arterial replacement/resection (66% vs. 9.7%, p<0.001) were more observed in BD. Conclusion. TAK differs from BD regarding clinical features and vascular involvement patterns. BD exhibits a higher rate of vascular complications.
Keywords: Behcet syndrome, Takayasu arteritis, Arteritis, Cardiovascular diseases


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