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Oct 01, 2023 Vol.30 No.4, pp. 209~277
Pathogenesis of ankylosing spondylitis. Gut microbiome produces short-chain fatty acids, tryptophan metabolites, and amino acids. Also, Paneth cells are source of IL-23 in the terminal ileum. HLA-B*27 provides arthritogenic peptide to TCR, and misfolded HLA-B*27 and accumulated protein induce UPR resul ting in production of IL-23. Mechanical stress in enthesis induce DAMPs and IL-1β.(J Rheum Dis 2023;30:220-233)

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Journal of Rheumatic Diseases

pISSN 2093-940X
eISSN 2233-4718
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