Journal of Rheumatic Diseases

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Case ReportJune 30, 2014

0 341 437

Muscle Weakness in a Patient with History of Poliomyelitis:A Differential Diagnosis for Post-polio Syndrome (PPS) and Dermatomyositis

Sang Hee An, Ha Young Na, Seong Hui Kang, Soo Youn Park, Hyung Min Yu, Chae Ho Lee, Ji Wan Kim, Se Woong Kwon, Junghwa Lee, Hae-Rim Kim, Sang-Heon Lee
J Rheum Dis 2014; 21(3): 147-150

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Oct 01, 2024 Vol.31 No.4, pp. 191~263

COVER PICTURE

Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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Most Cited

Disentangling Diagnosis and Management of Fibromyalgia

Ji-Hyoun Kang, M.D., Ph.D., Sung-Eun Choi, M.D., Dong-Jin Park, M.D., Ph.D., Shin-Seok Lee, M.D., Ph.D.
J Rheum Dis 2022;29: 4-13
The Mechanism of the NLRP3 Inflammasome Activation and Pathogenic Implication in the Pathogenesis of Gout

Seong-Kyu Kim, M.D., Ph.D.
J Rheum Dis 2022;29: 140-153

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_{Schematic structure of NLRP3 inflammasome complex. The NLRP3 inflammasome complex consists of the NLRP3 scaffold, the ASC adaptor, and pro-caspase-1 proteins. Deletion of the CARD domain and activation of caspase-1 domain of pro-caspase-1 leads to formation of active caspase-1, then resulting in cleavage from pro-IL-1β to IL-1β. ASC: apoptosis-associated speck-like protein, CARD: caspase activation and recruitment domain, IL: interleukin, LRR: leucine-rich repeat, NACHT: neuronal apoptosis inhibitory protein (NAIP), MHC class II transcription activator (CIITA), incompatibility locus protein from Podospora anserina (HET-E), and telomerase-associated protein (TP1), NLRP3: NACHT, LRR, and PYD domains-containing protein 3, PYD: pyrin domain.}|@|~(^,^)~|@|_{Signal pathway for NLRP3 inflammasome activation. Activation of the NLRP3 inflammasome is essential for two steps such as priming (signal 1) and activation (signal 2). In priming step, activation of TLR or TNFR after exposure of danger signals facilitates NF-κB signaling pathway for initiating transcription and production of precursor of pro-inflammatory cytokine including pro-IL-1β and pro-IL-18. Next, sensing PAMPs or DAMPs triggers NLRP3 oligomerization and ASC and pro-caspase-1 recruitment (signal 2). Autocleavage and activation of caspase-1 results in maturation and release of pro-inflammatory cytokines IL-1β and IL-18. PAMPs: pathogen-associated molecular patterns, DAMPs: damage-associated molecular patterns, ASC: apoptosis-associated speck-like protein, CARD: caspase activation and recruitment domain, TLR: toll-like receptor, TNFR: tumor necrosis factor receptor, ROS: reactive oxygen species, IKK: IκB kinase, IL: interleukin, NF-κB: nuclear factor-κB, NACHT: neuronal apoptosis inhibitory protein (NAIP), MHC class II transcription activator (CIITA), incompatibility locus protein from Podospora anserina (HET-E), and telomerase-associated protein (TP1), NLRP3: NACHT, LRR, and PYD domains-containing protein 3.}|@|~(^,^)~|@|_{Mechanism for IL-1β/IL-1R-related inflammatory signaling pathway. IL-1β/IL-1R complex is generated by the heterodimer signaling receptors and cytokine. The TIR domain, an intercellular signaling protein motif between receptors and adaptors, associates with adaptor MyD88, thus resulting in recruitment of IRAK and dimerized TRAF6. This subsequently activates multiple downstream signaling pathways including IκB-kinase complex and MAPK. Activation of transcription factors including NF-κB and AP-1 results in diverse pro-inflammatory cytokines and chemokines. IL-1β: interleukin-1β, IL-1RI: interleukin-1 receptor type I, TIR: toll/interleukin-1 receptor, MyD88: myeloid differentiation primary response 88, IRAK: interleukin-1 receptor associated kinase, TRAF6: TNF receptor-associated factor 6, TNF: tumor necrosis factor, NF-κB: nuclear factor-κB.}

J Rheum Dis 2022;29:140~153 https://doi.org/10.4078/jrd.2022.29.3.140

Related article in JRD

Juvenile Dermatomyositis

Case ReportJune 30, 2014

Muscle Weakness in a Patient with History of Poliomyelitis:A Differential Diagnosis for Post-polio Syndrome (PPS) and Dermatomyositis

Most Keyword ? What is Most Keyword? It is most registrated keyword in articles at this journal during for 2 years.

What is Most Keyword?

Most Read

Disentangling Diagnosis and Management of Fibromyalgia

Juvenile Dermatomyositis

Most Cited

Disentangling Diagnosis and Management of Fibromyalgia

The Mechanism of the NLRP3 Inflammasome Activation and Pathogenic Implication in the Pathogenesis of Gout

Editorial Office

Most Keyword ?
What is Most Keyword?

It is most registrated keyword in articles at this journal during for 2 years.