Journal of Rheumatic Diseases

Table. 2.

Multiple logistic regression analysis of mitochondrial haplogroups associated with osteoarthritis

Haplogroup Non-progression (n=143) Progression (n=166) Unadjusted Adjusted*


B RR (95% CI) p-value B RR (95% CI) p-value
A 14 (9.8) 16 (9.6) −0.017 0.98 (0.46∼2.09) 0.964 −0.167 0.85 (0.38∼1.87) 0.680
B 21 (14.7) 28 (16.9) 0.164 1.18 (0.64∼2.18) 0.601 0.185 1.20 (0.63∼2.28) 0.571
D 1 (0.7) 0 (0.0) −21.359 - 1.000 −20.721 - 1.000
D4 19 (13.3) 12 (7.2) −0.676 0.51 (0.24∼1.09) 0.081 −0.586 0.56 (0.25∼1.23) 0.149
D4a 9 (6.3) 9 (5.4) −0.158 0.85 (0.33∼2.21) 0.744 −0.232 0.79 (0.30∼2.12) 0.644
D4b 2 (1.4) 1 (0.6) −0.850 0.43 (0.04∼4.76) 0.489 −0.637 0.53 (0.05∼6.06) 0.608
D4b2 9 (6.3) 11 (6.6) 0.055 1.06 (0.42∼2.63) 0.906 0.112 1.12 (0.44∼2.87) 0.816
D4j 3 (2.1) 2 (1.2) −0.564 0.57 (0.09∼3.45) 0.540 0.017 1.02 (0.15∼6.77) 0.986
D4e 4 (2.8) 7 (4.2) 0.425 1.53 (0.44∼5.34) 0.505 0.401 1.49 (0.41∼5.39) 0.540
D4a/D4b 0 (0.0) 1 (0.6) 21.060 - 1.000 20.804 - 1.000
D5 12 (8.4) 13 (7.8) −0.075 0.93 (0.41∼2.10) 0.857 0.003 1.00 (0.43∼2.34) 0.994
F 11 (7.7) 17 (10.2) 0.314 1.37 (0.62∼3.03) 0.438 0.277 1.32 (0.58∼2.99) 0.508
G 8 (5.6) 11 (6.6) 0.180 1.20 (0.47∼3.06) 0.707 0.184 1.20 (0.46∼3.16) 0.709
M 1 (0.7) 2 (1.2) 0.549 1.73 (0.16∼19.30) 0.655 0.488 1.63 (0.14∼18.47) 0.694
M7 9 (6.3) 12 (7.2) 0.149 1.16 (0.47∼2.84) 0.745 0.049 1.05 (0.42∼2.62) 0.916
M8 8 (5.6) 11 (6.6) 0.180 1.20 (0.47∼3.06) 0.707 −0.010 0.99 (0.37∼2.63) 0.984
M9 3 (2.1) 2 (1.2) −0.564 0.57 (0.09∼3.45) 0.540 −0.384 0.68 (0.11∼4.26) 0.681
M10 2 (1.4) 0 (0.0) −21.366 - 0.999 −22.129 - 0.999
N9 7 (4.9) 11 (6.6) 0.321 1.38 (0.52∼3.66) 0.519 0.398 1.49 (0.54∼4.10) 0.440
R 0 (0.0) 0 (0.0) - - - - - -
Macro-haplogroup M 90 (62.9) 94 (56.6) −0.263 0.77 (0.49∼1.21) 0.260 −0.227 0.80 (0.50∼1.28) 0.348
Macro-haplogroup N 53 (37.1) 72 (43.4) 0.263 1.30 (0.82∼2.06) 0.260 0.227 1.26 (0.78∼2.02) 0.348
Macro-haplogroup D§ 59 (41.3) 56 (33.7) −0.322 0.72 (0.46∼1.15) 0.173 −0.209 0.81 (0.50∼1.31) 0.394
Macro-haplogroup R 32 (22.4) 45 (27.1) 0.255 1.29 (0.77∼2.17) 0.338 0.255 1.29 (0.75∼2.22) 0.357

Values are presented as number (%). RR: relative risk, CI: confidence interval. *Adjusted for age, sex, body mass index. Macro-haplogroupM: D, D4, D4a, D4b, D4b2, D4j, D4e, D4a/D4b, D5, G, M, M7, M8, M9, and M10. Macro-haplogroup N: A, B, F, N9, and R. §Macro-haplogroup D: D, D4, D4a, D4b, D4b2, D4j, D4e, D4a/D4b, and D5. Macro-haplogroup R: B, F, and R.

J Rheum Dis 2020;27:168~173 https://doi.org/10.4078/jrd.2020.27.3.168
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