Journal of Rheumatic Diseases

Table. 2.

Adjusted odds ratio for the association between serum uric acid and reduced renal function in total, men, and women participants

Variable Total Men Women
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Age (yr) 1.097 (1.091∼1.103) <0.001 1.087 (1.078∼1.096) <0.001 1.107 (1.099∼1.116) <0.001
Women 2.491 (2.201∼2.818) <0.001
Drinking status
Never Reference Reference Reference
Former 0.977 (0.821∼1.161) 0.790 0.906 (0.733∼1.120) 0.362 0.868 (0.609∼1.235) 0.431
Current 0.732 (0.665∼0.806) <0.001 0.639 (0.554∼0.736) <0.001 0.828 (0.728∼0.941) 0.004
Smoking status
Never Reference Reference Reference
Former 0.994 (0.873∼1.133) 0.930 0.980 (0.852∼1.128) 0.783 1.373 (0.923∼2.041) 0.117
Current 0.922 (0.790∼1.075) 0.299 0.953 (0.801∼1.134) 0.588 0.853 (0.589∼1.236) 0.401
Exercise 1.013 (0.937∼1.094) 0.752 1.063 (0.939∼1.204) 0.334 0.979 (0.887∼1.081) 0.674
Medical history
Hypertension 1.448 (1.333∼1.572) <0.001 1.632 (1.436∼1.853) <0.001 1.311 (1.176∼1.461) <0.001
Diabetes 1.604 (1.442∼1.784) <0.001 1.630 (1.389∼1.913) <0.001 1.571 (1.361∼1.813) <0.001
Cardiovascular disease 1.667 (1.444∼1.923) <0.001 1.703 (1.392∼2.084) <0.001 1.615 (1.316∼1.981) <0.001
Cerebrovascular disease 1.828 (1.495∼2.236) <0.001 1.840 (1.388∼2.439) <0.001 1.803 (1.352∼2.404) <0.001
Malignancy 1.136 (0.939∼1.375) 0.189 1.622 (1.209∼2.177) 0.001 0.918 (0.711∼1.185) 0.511
Body mass index (kg/m2) 0.994 (0.981∼1.007) 0.372 1.033 (1.009∼1.056) 0.006 0.970 (0.954∼0.987) <0.001
BUN (mg/dL) 1.200 (1.191∼1.210) <0.001 1.210 (1.194∼1.225) <0.001 1.192 (1.180∼1.205) <0.001
Proteinuria 2.725 (2.368∼3.135) <0.001 2.838 (2.320∼3.471) <0.001 2.578 (2.119∼3.137) <0.001
Glycosuria 1.534 (1.196∼1.967) 0.001 1.291 (0.923∼1.807) 0.136 1.808 (1.249∼2.618) 0.002
Uric acid category (mg/dL)
≤2.0 1.715 (0.945∼3.111) 0.076 5.003 (1.405∼17.809) 0.013 1.377 (0.696∼2.724) 0.358
2.1∼3.0 0.426 (0.315∼0.576) <0.001 1.444 (0.766∼2.721) 0.256 0.336 (0.238∼0.475) <0.001
3.1∼4.0 0.674 (0.585∼0.777) <0.001 1.061 (0.727∼1.547) 0.760 0.632 (0.542∼0.737) <0.001
4.1∼5.0 Reference Reference Reference
5.1∼6.0 2.070 (1.848∼2.318) <0.001 1.693 (1.328∼2.160) <0.001 2.252 (1.980∼2.562) <0.001
6.1∼7.0 4.132 (3.638∼4.692) <0.001 3.240 (2.556∼4.106) <0.001 5.030 (4.287∼5.901) <0.001
>7.0 11.884 (10.395∼13.588) <0.001 10.417 (8.287∼13.094) <0.001 11.821 (9.608∼14.543 <0.001

OR: odds ratio, CI: confidence interval, BP: blood pressure, BUN: blood urea nitrogen, HDL: high density lipoprotein, eGFR: estimated glomerular filtration rate, r-GT: gamma-glutamyl transferase, AST: aspartate transaminase, ALT: alanine transaminase.

J Rheum Dis 2021;28:225~233 https://doi.org/10.4078/jrd.2021.28.4.225
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