Journal of Rheumatic Diseases

Table. 3.

Univariate and multivariate Cox regression analyses for predictors of renal response

Variable Univariate analysis Multivariate analysis


HR 95% CI p-value HR 95% CI p-value
Age (yr) 0.986 0.947∼1.026 0.485
Female 1.487 0.191∼11.564 0.705
Duration since SLE diagnosis (yr) 1.016 0.936∼1.103 0.704
Duration since LN diagnosis (yr) 0.969 0.866∼1.085 0.588
ISN/RPS classification
Class III 1.566 0.495∼4.956 0.446
Class IV 0.475 0.142∼1.588 0.227
Class III/V or IV/V 0.215 0.028∼1.671 0.142
Activity index* 0.899 0.760∼1.062 0.210
Chronicity index* 0.905 0.690∼1.186 0.468
Refractory LN (vs. relapsing LN) 0.291 0.078∼1.083 0.066
Previous immunosuppressants
Cyclophosphamide 0.221 0.063∼0.780 0.019
Mycophenolate mofetil 22.295 0.001∼661,999.761 0.555
Azathioprine 2.061 0.557∼7.626 0.279
Tacrolimus 0.346 0.071∼1.676 0.187
Immunosuppressants before the start of rituximab
Cyclophosphamide 0.367 0.047∼2.858 0.339
Mycophenolate mofetil 1.676 0.503∼5.584 0.400
Azathioprine 2.995 0.360∼24.917 0.310
Tacrolimus 1.791 0.567∼5.654 0.320
Hydroxychloroquine 2.722 0.350∼21.175 0.339
Baseline prednisolone dose (mg/day) 1.003 0.972∼1.034 0.872
Baseline laboratory findings
Normal GFR level 11.331 2.305∼55.710 0.003 9.256 1.767∼48.481 0.008
GFR≥60 mL/min/1.73 m2 9.534 1.215∼74.823 0.032
UPCR (mg/g) 1.000 0.999∼1.000 0.174
Microscopic hematuria 1.285 0.407∼4.061 0.669
Serum albumin (g/dL) 0.829 0.379∼1.814 0.640
C3 (mg/dL) 0.976 0.954∼0.999 0.038
C4 (mg/dL) 0.938 0.874∼1.007 0.075
Anti-dsDNA titer (IU/mL) 1.000 0.999∼1.001 0.921
Anti-ENA positivity
Anti-RNP 1.857 0.564∼6.114 0.309
Anti-Sm 1.155 0.337∼3.957 0.819
Anti-Ro 2.701 0.709∼10.292 0.145
Anti-La 10.406 2.010∼53.878 0.005 5.478 1.072∼27.992 0.041
Baseline SLEDAI-2K score 1.019 0.915∼1.135 0.729
Concomitant treatment
Cyclophosphamide 0.673 0.086∼5.232 0.705
Mycophenolate mofetil 0.715 0.230∼2.228 0.563
Azathioprine 2.995 0.360∼24.917 0.310
Tacrolimus 1.253 0.397∼3.957 0.701
Cumulative dose of prednisolone (mg/day) 1.035 0.969∼1.106 0.307

HR: hazard ratio, CI: confidence interval, SLE: systemic lupus erythematosus, LN: lupus nephritis, ISN/RPS: International Society of Nephrology/Renal Pathology Society, GFR: glomerular filtration rate, UPCR: urine protein to creatinine ratio, SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000. *Three patients were excluded because of missing data. One patient was excluded because of missing data.

J Rheum Dis 2022;29:22~32 https://doi.org/10.4078/jrd.2022.29.1.22
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