Journal of Rheumatic Diseases

Table. 1.

Baseline characteristics of patients in normal and decreased glomerular filtration rate groups

Variable Normal GFR (n=11) Decreased GFR (n=11) p-value
Age (yr) 31 (24∼49) 43 (24∼56) 0.300
Female 10 (90.9) 10 (90.9) 1.000
Duration since SLE diagnosis (yr) 12.4 (3.2∼18.3) 8.7 (6.8∼15.4) 1.000
Duration since LN diagnosis (yr) 5.7 (2.4∼8.1) 5.8 (4.2∼10.1) 0.519
Duration since last kidney biopsy (yr) 2.7 (1.0∼6.4) 5.8 (3.3∼10.1) 0.116
ISN/RPS classification
Class III 6 (54.5) 5 (45.5) 0.670
Class IV 4 (36.4) 6 (54.5) 0.392
Pure class V 1 (9.1) 0 (0) 1.000
Class III/V 1 (9.1) 2 (18.2) 1.000
Class IV/V 0 (0) 2 (18.2) 0.476
Activity index 6 (3∼9) 8 (5∼11)* 0.492
Chronicity index 2 (1∼4) 4 (2∼5)* 0.310
Refractory LN 2 (18.2) 8 (72.7) 0.010
Previous immunosuppressants
Cyclophosphamide 6 (54.5) 11 (100) 0.035
Mycophenolate mofetil 11 (100) 10 (90.9) 1.000
Azathioprine 7 (63.6) 7 (63.6) 1.000
Tacrolimus 9 (81.8) 11 (100) 0.476
Hydroxychloroquine 11 (100) 11 (100) N/A
Immunosuppressants before the start of rituximab
Cyclophosphamide 0 (0) 4 (36.4) 0.090
Mycophenolate mofetil 8 (72.7) 4 (36.4) 0.087
Azathioprine 1 (9.1) 0 (0) 1.000
Tacrolimus 7 (63.6) 3 (27.3) 0.087
Hydroxychloroquine 11 (100) 7 (63.6) 0.090
Glucocorticoid treatment 8 (72.7) 8 (72.7) 1.000
Prednisolone dose (mg/day) 5.0 (0∼20.0) 7.5 (0∼20.0) 0.949
Rituximab regimen
1,000 mg×2 infusions 10 (90.9) 6 (54.5) 0.149
500 mg×4 infusions 1 (9.1) 3 (27.3) 0.586
500 mg×3 infusions 0 (0) 1 (9.1) 1.000
500 mg×2 infusions 0 (0) 1 (9.1) 1.000
Laboratory finding
Serum creatinine (mg/dL) 0.70 (0.48∼0.75) 1.59 (0.97∼2.15) <0.001
GFR (mL/min/1.73 m2) 116 (101∼123) 39 (27∼79) <0.001
UPCR (mg/g) 1,275 (920∼2,199) 3,110 (2,264∼5,682) 0.008
UPCR<1,000 mg/g 4 (36.4) 0 (0) 0.090
UPCR≥3,000 mg/g 2 (18.2) 7 (63.6) 0.080
Microscopic hematuria 5 (45.5) 4 (36.4) 1.000
Serum albumin (g/dL) 3.1 (2.8∼3.4) 3.2 (1.9∼3.6) 0.748
C3 (mg/dL) 52.1 (41.9∼90.7) 76.2 (38.7∼109.0) 0.438
C4 (mg/dL) 9.8 (4.5∼15.1) 22.1 (14.6∼25.2) 0.007
Anti-dsDNA titer (IU/mL) 47.7 (7.2∼488.0) 11.9 (3.5∼33.8) 0.401
Anti-ENA positivity
Anti-Ro 7/10 (70) 5/11 (45.5) 0.387
Anti-RNP 6/10 (60) 4/11 (36.4) 0.395
Anti-Sm 4/10 (40) 4/11 (36.4) 1.000
Anti-La 2/10 (20) 1/11 (9.1) 0.586
SLEDAI-2K score 12 (6∼16) 8 (6∼16) 0.606

Data are expressed as median (interquartile range) or number (%). GFR: glomerular filtration rate, SLE: systemic lupus erythematosus, LN: lupus nephritis, ISN/RPS: International Society of Nephrology/Renal Pathology Society, UPCR: urine protein to creatinine ratio, SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000, N/A: not available. *Three patients were excluded because of missing data.

J Rheum Dis 2022;29:22~32 https://doi.org/10.4078/jrd.2022.29.1.22
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