Journal of Rheumatic Diseases

Table. 1.

Mendelian randomization estimates from three methods analyzing the causal effect of RA and SLE on the risk of ASD

Method Number of SNPs Beta coefficient Standard error Association p-value Cochran Q statistic Heterogeneity
p-value
RA
Inverse variance weighted 33 −0.077 0.041 0.062 37.25 0.240
MR-Egger 33 −0.062 0.079 0.434 37.19 0.205
Weighted median 33 −0.071 0.058 0.223 NA NA
SLE
Inverse variance weighted 28 0.014 0.021 0.493 19.34 0.857
MR-Egger 28 0.048 0.043 0.273 18.53 0.856
Weighted median 28 0.045 0.030 0.130 NA NA

RA: rheumatoid arthritis, SLE: systemic lupus erythematosus, ASD: autism spectrum disorder, MR: Mendelian randomization, SNP: single nucleotide polymorphism, NA: not available.

J Rheum Dis 2022;29:46~51 https://doi.org/10.4078/jrd.2022.29.1.46
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