On-line First

J Rheum Dis

Published online October 18, 2023

© Korean College of Rheumatology

Radiologic approach and progressive exploration of connective tissue disease-related interstitial lung disease: meeting the curiosity of rheumatologists

Hyeji Jeon, M.D.1 , Bo Da Nam, M.D.2 , Chong-Hyeon Yoon, M.D, Ph.D.3 , Hyun-Sook Kim, M.D, Ph.D.1

1Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 2Department of Radiology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence to : Hyun-Sook Kim, https://orcid.org/0000-0001-9213-7140
Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwanro, Yongsan-gu, Seoul 04401, Korea. E-mail: healthyra@schmc.ac.kr
Chong-Hyeon Yoon, https://orcid.org/0000-0003-2305-4637
Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea, Eunpyeong St. Mary’s Hospital, 1021 Tongil-ro, Eunpyeong-gu, Seoul 03312, Korea. E-mail: chyoon@catholic.ac.kr

Received: July 28, 2023; Revised: September 10, 2023; Accepted: September 11, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interstitial lung disease (ILD) is often observed in connective tissue diseases (CTDs), frequently in rheumatoid arthritis, systemic sclerosis, primary Sjögren’s syndrome, and inflammatory myositis. Early detection of ILDs secondary to rheumatic diseases is important as timely initiation of proper management affects the prognosis. Among many imaging modalities, high-resuloution computed tomography (HRCT) serves the gold standard for finding early lung inflammatory and fibrotic changes as well as monitoring afterwards because of its superior spatial resolution. Additionally, lung ultrasound (LUS) and magnetic resonance imaging (MRI) are the rising free-radiation imaging tools that can get images of lungs of CTD-ILD. In this review article, we present the subtypes of ILD images found in each CTD acquired by HRCT as well as some images taken by LUS and MRI with comparative HRCT scans. It is expected that this discussion would be helpful in discussing recent advances in imaging modalities for CTD-ILD and raising critical points for diagnosis and tracing of the images from the perspective of rheumatologists.

Keywords Interstitial lung disease, Connective tissue diseases, Pulmonary fibrosis, Rheumatology

Article

On-line First

J Rheum Dis

Published online October 18, 2023

Copyright © Korean College of Rheumatology.

Radiologic approach and progressive exploration of connective tissue disease-related interstitial lung disease: meeting the curiosity of rheumatologists

Hyeji Jeon, M.D.1 , Bo Da Nam, M.D.2 , Chong-Hyeon Yoon, M.D, Ph.D.3 , Hyun-Sook Kim, M.D, Ph.D.1

1Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 2Department of Radiology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence to:Hyun-Sook Kim, https://orcid.org/0000-0001-9213-7140
Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwanro, Yongsan-gu, Seoul 04401, Korea. E-mail: healthyra@schmc.ac.kr
Chong-Hyeon Yoon, https://orcid.org/0000-0003-2305-4637
Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea, Eunpyeong St. Mary’s Hospital, 1021 Tongil-ro, Eunpyeong-gu, Seoul 03312, Korea. E-mail: chyoon@catholic.ac.kr

Received: July 28, 2023; Revised: September 10, 2023; Accepted: September 11, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interstitial lung disease (ILD) is often observed in connective tissue diseases (CTDs), frequently in rheumatoid arthritis, systemic sclerosis, primary Sjögren’s syndrome, and inflammatory myositis. Early detection of ILDs secondary to rheumatic diseases is important as timely initiation of proper management affects the prognosis. Among many imaging modalities, high-resuloution computed tomography (HRCT) serves the gold standard for finding early lung inflammatory and fibrotic changes as well as monitoring afterwards because of its superior spatial resolution. Additionally, lung ultrasound (LUS) and magnetic resonance imaging (MRI) are the rising free-radiation imaging tools that can get images of lungs of CTD-ILD. In this review article, we present the subtypes of ILD images found in each CTD acquired by HRCT as well as some images taken by LUS and MRI with comparative HRCT scans. It is expected that this discussion would be helpful in discussing recent advances in imaging modalities for CTD-ILD and raising critical points for diagnosis and tracing of the images from the perspective of rheumatologists.

Keywords: Interstitial lung disease, Connective tissue diseases, Pulmonary fibrosis, Rheumatology

JRD
Oct 01, 2023 Vol.30 No.4, pp. 209~277
COVER PICTURE
Pathogenesis of ankylosing spondylitis. Gut microbiome produces short-chain fatty acids, tryptophan metabolites, and amino acids. Also, Paneth cells are source of IL-23 in the terminal ileum. HLA-B*27 provides arthritogenic peptide to TCR, and misfolded HLA-B*27 and accumulated protein induce UPR resul ting in production of IL-23. Mechanical stress in enthesis induce DAMPs and IL-1β.(J Rheum Dis 2023;30:220-233)

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