Methotrexate is often used in patients with systemic lupus erythematosus for effective disease controlsand ste-roid-sparing, and has been known to involve the develop-ment of lymphoproliferative disorders for patients with autoimmune diseases. We report a case of spontaneous re-gression of Epstein-Barr virus-positive methotrexate-asso-ciated Hodgkin's lymphoma in a 24-year-old woman with systemic lupus erythematosus. Following 6 months of treatment with low-dose methotrexate, the patient devel-oped a neck mass in the right submandibular area. A com-puted tomography scan of the neck, chest and abdomen revealed multiple enlarged lymph nodes. Excisional biopsy of the neck masses confirmed infiltrations of malignant lymphoid cells that were positive for CD15, CD30, and Epstein-Barr virus-encoded RNA. Reduction of the mass was observed 3 weeks after withdrawing from the metho-trexate treatment. At 7 months after initial presentation, computed tomography revealed near-complete regression of lymphadenopathy. After 30 months, the patient was still in complete clinical remission.

Keywords: Hodgkin's lymphoma, Methotrexate, Systemic lupus erythematosus