Case Report
J Rheum Dis 2014; 21(3): 151-155
Published online June 30, 2014
© Korean College of Rheumatology
Monoclonal Gammopathy of Undetermined Significance가 동반된 강직성 척추염 환자에서 발생한 AA형 및 AL형 심아밀로이드증
김우현1ㆍ김선아1ㆍ윤경진1ㆍ나수진1ㆍ현지인1ㆍ정정임2ㆍ곽승기1ㆍ박성환1
가톨릭대학교 서울성모병원 류마티스내과1, 영상의학과2
Coexistence of AA and AL Cardiac Amyloidosis in a Patient with Ankylosing Spondylitis Accompanying Monoclonal Gammopathy of Undetermined Significance
Correspondence to : Seung-Ki Kwok
Amyloidosis is a clinical disorder caused by extracellular deposition of proteinaceous insoluble fibrils in various tis-sues, resulting in organ compromise. Amyloid L (AL) amy-loidosis is the most common type of systemic amyloidosis, which occurs in association with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS). Secondary amyloid A (AA) amyloidosis is a com-plication of chronic inflammatory conditions, such as rheu-matoid arthritis or ankylosing spondylitis. We report a case of a 49-year-old manwith a 11-year history of anky-losing spondylitis, who was recently diagnosed with MGUS presented with cardiac amyloidosis of both the AA and AL types. We report this case along with a review of relevant literature.
Keywords Cardiac amyloidosis, Ankylosing spondylitis, Monoclonal gammopathy of undetermined significance
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Case Report
J Rheum Dis 2014; 21(3): 151-155
Published online June 30, 2014
Copyright © Korean College of Rheumatology.
Monoclonal Gammopathy of Undetermined Significance가 동반된 강직성 척추염 환자에서 발생한 AA형 및 AL형 심아밀로이드증
김우현1ㆍ김선아1ㆍ윤경진1ㆍ나수진1ㆍ현지인1ㆍ정정임2ㆍ곽승기1ㆍ박성환1
가톨릭대학교 서울성모병원 류마티스내과1, 영상의학과2
Coexistence of AA and AL Cardiac Amyloidosis in a Patient with Ankylosing Spondylitis Accompanying Monoclonal Gammopathy of Undetermined Significance
Woohyeon Kim1, Seon A Kim1, Kyung Jin Yun1, Soo Jin Na1, Ji In Hyun1, Jung Im Jung2, Seung-Ki Kwok1, Sung-Hwan Park1
Division of Rheumatology, Departments of Internal Medicine1, Radiology2, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence to:Seung-Ki Kwok
Abstract
Amyloidosis is a clinical disorder caused by extracellular deposition of proteinaceous insoluble fibrils in various tis-sues, resulting in organ compromise. Amyloid L (AL) amy-loidosis is the most common type of systemic amyloidosis, which occurs in association with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS). Secondary amyloid A (AA) amyloidosis is a com-plication of chronic inflammatory conditions, such as rheu-matoid arthritis or ankylosing spondylitis. We report a case of a 49-year-old manwith a 11-year history of anky-losing spondylitis, who was recently diagnosed with MGUS presented with cardiac amyloidosis of both the AA and AL types. We report this case along with a review of relevant literature.
Keywords: Cardiac amyloidosis, Ankylosing spondylitis, Monoclonal gammopathy of undetermined significance
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