Behcet’s disease is a systemic vasculitis, characterized by recurrent oral aphthous ulcers, recurrent genital ulcers, skin lesion, and ocular involvement. Monoclonal antibody to the tumor necrosis factor-α (TNF-α) is considered as a possible therapeutic approach to achieve clinical im-provement, preventing relapse in Behcet’s disease re-fractory to conventional anti-inflammatory drugs or im-munosuppressive durgs. We report the use of infliximab, which is one of the TNF-α monoclonal antibodies, in a 17-year-old girl with Behcet’s disease exhibiting severe mucocutaneous, ocular and neurological involvement re-fractory to standard treatment.

Keywords: Child, Neuro-Behcet disease, Infliximab