Original Article

J Rheum Dis 2013; 20(6): 356-360

Published online December 30, 2013

© Korean College of Rheumatology

TNF-α 길항제가 적응이 되는 류마티스관절염 환자들의 임상양상

손경민ㆍ정영옥ㆍ김인제ㆍ김범준ㆍ이성연ㆍ문소영ㆍ서영일ㆍ김현아

한림대학교 의과대학 류마티스내과학교실

Received: October 14, 2013; Revised: December 1, 2013; Accepted: December 4, 2013

Clinical Characteristics of Korean Rheumatoid Arthritis Patients with Indications for TNF-α Blocker

Kyeong Min Son, Young Ok Jung, In Je Kim, Bum Jun Kim, Seung Yun Lee, So Young Mun, Young Il Seo, Hyun Ah Kim

Division of Rheumatology, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea

Correspondence to : Hyun Ah Kim

Received: October 14, 2013; Revised: December 1, 2013; Accepted: December 4, 2013

Abstract

Objective. The aim of this study was to examine clinical characteristics of Korean rheumatoid arthritis (RA) patients with clinically indications for TNF-α blocker, and to compare their clinical parameters with the Korean National Health Insurance reimbursement criteria.Methods. Data were obtained from a registry of RA patients who visited rheumatology clinics of Hallym University affiliated hospitals. Among patients who were previously prescribed DMARDs for more than three months, rheumatologists selected patients clinically indicated for TNF-a blocker. The clinical characteristics at the time TNF-α blocker use was deemed indicated were examined. Radiographic damage was quantified by Modified Sharp van der Heijde score in hand and foot simple AP radiograph.Results. From August 2010 to January 2013, five rheumatologists in four hospitals selected 109 patients clinically indicated for TNF-α blocker. When TNF-α blocker was considered, mean DAS28 was 5.2 (range 2.1∼8.05), mean swollen joint count was 6 (range 0∼22), mean tender joint count was 10.6 (range 0∼28), mean ESR was 43.2 mm/hr (range 1∼140) and mean CRP was 2.5 mg/dL (range 0.1∼18.3). The mean total modified Sharp van der Heijde score was 32.72 (range 0∼240). Eighty one percent of subjects did not have enough active joints to satisfy the Korean National Health Insurance reimbursement standard. Conclusion. Our results show that patients with clinically indications for TNF-α blocker had a broad range of disease activity and clinical parameters, and the majority did not meet the Korean National Health Insurance reimbursement criteria

Keywords Rheumatoid arthritis, TNF-α blocker, Korean National Health Insurance reimbursement criteria

Article

Original Article

J Rheum Dis 2013; 20(6): 356-360

Published online December 30, 2013

Copyright © Korean College of Rheumatology.

TNF-α 길항제가 적응이 되는 류마티스관절염 환자들의 임상양상

손경민ㆍ정영옥ㆍ김인제ㆍ김범준ㆍ이성연ㆍ문소영ㆍ서영일ㆍ김현아

한림대학교 의과대학 류마티스내과학교실

Received: October 14, 2013; Revised: December 1, 2013; Accepted: December 4, 2013

Clinical Characteristics of Korean Rheumatoid Arthritis Patients with Indications for TNF-α Blocker

Kyeong Min Son, Young Ok Jung, In Je Kim, Bum Jun Kim, Seung Yun Lee, So Young Mun, Young Il Seo, Hyun Ah Kim

Division of Rheumatology, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea

Correspondence to:Hyun Ah Kim

Received: October 14, 2013; Revised: December 1, 2013; Accepted: December 4, 2013

Abstract

Objective. The aim of this study was to examine clinical characteristics of Korean rheumatoid arthritis (RA) patients with clinically indications for TNF-α blocker, and to compare their clinical parameters with the Korean National Health Insurance reimbursement criteria.Methods. Data were obtained from a registry of RA patients who visited rheumatology clinics of Hallym University affiliated hospitals. Among patients who were previously prescribed DMARDs for more than three months, rheumatologists selected patients clinically indicated for TNF-a blocker. The clinical characteristics at the time TNF-α blocker use was deemed indicated were examined. Radiographic damage was quantified by Modified Sharp van der Heijde score in hand and foot simple AP radiograph.Results. From August 2010 to January 2013, five rheumatologists in four hospitals selected 109 patients clinically indicated for TNF-α blocker. When TNF-α blocker was considered, mean DAS28 was 5.2 (range 2.1∼8.05), mean swollen joint count was 6 (range 0∼22), mean tender joint count was 10.6 (range 0∼28), mean ESR was 43.2 mm/hr (range 1∼140) and mean CRP was 2.5 mg/dL (range 0.1∼18.3). The mean total modified Sharp van der Heijde score was 32.72 (range 0∼240). Eighty one percent of subjects did not have enough active joints to satisfy the Korean National Health Insurance reimbursement standard. Conclusion. Our results show that patients with clinically indications for TNF-α blocker had a broad range of disease activity and clinical parameters, and the majority did not meet the Korean National Health Insurance reimbursement criteria

Keywords: Rheumatoid arthritis, TNF-α blocker, Korean National Health Insurance reimbursement criteria

JRD
Oct 01, 2024 Vol.31 No.4, pp. 191~263
COVER PICTURE
Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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