Original Article

J Rheum Dis 2016; 23(2): 101-108

Published online April 30, 2016

© Korean College of Rheumatology

류마티스관절염에 동반된 폐침범의 양상과 관련인자 분석

김지원1ㆍ이화정1ㆍ황준현2ㆍ박성훈1ㆍ이혜선1ㆍ김성규1ㆍ최정윤1

대구가톨릭대학교 의과대학 1내과학교실 류마티스내과, 2예방의학교실

Received: September 10, 2015; Revised: October 14, 2015; Accepted: October 15, 2015

Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis

Ji-Won Kim1, Hwajeong Lee1, Jun Hyun Hwang2, Sung-Hoon Park1, Hye-Sun Lee1, Seong-Kyu Kim1, Jung-Yoon Choe1

1Division of Rheumatology, Department of Internal Medicine, 2Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea

Correspondence to : Jung-Yoon Choe
Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 42472, Korea. E-mail : jychoe@cu.ac.kr

Received: September 10, 2015; Revised: October 14, 2015; Accepted: October 15, 2015

Abstract

Objective. This study examined lung involvement in patients with rheumatoid arthritis (RA) and identified factors associated with airway disease (AD) and interstitial lung disease (ILD). Methods. A total of 507 RA patients were enrolled in a cross-sectional study. Lung involvement was assessed by high-resolution computed tomography scan. The patient groups were classified according to normal, AD, and ILD. Multinomial logistic regression analysis was performed to identify factors associated with AD and ILD. Results. The most frequent lung involvement was AD (38.3%) followed by ILD (12.6%). Old age (adjust odds ratio [aOR] 2.58, 95% confidence interval [CI] 1.70 to 3.90 for AD; aOR 4.38, 95% CI 2.30 to 8.35 for ILD), male gender (aOR 2.57, 95% CI 1.22 to 5.42 for AD; aOR 5.48, 95% CI 2.20 to 13.65 for ILD) were factors associated with AD and ILD in RA patients. ILD was associated with short disease duration (aOR 0.30, 95% CI 0.14 to 0.62), AD was associated with high titers of anti-cyclic citrullinated peptides antibodies (anti-CCP; aOR 1.61, 95% CI 1.07 to 2.44). Conclusion. AD was the most frequent lung involvement in patients with RA. Old age and male gender were both associated with AD and ILD. Short disease duration was associated with ILD. High titers of anti-CCP was associated with AD. (J Rheum Dis 2016;23:101-108)

Keywords Rheumatoid arthritis, Obstructive lung diseases, Interstitial lung diseases, X-ray computed tomography, Risk factors

Article

Original Article

J Rheum Dis 2016; 23(2): 101-108

Published online April 30, 2016

Copyright © Korean College of Rheumatology.

류마티스관절염에 동반된 폐침범의 양상과 관련인자 분석

김지원1ㆍ이화정1ㆍ황준현2ㆍ박성훈1ㆍ이혜선1ㆍ김성규1ㆍ최정윤1

대구가톨릭대학교 의과대학 1내과학교실 류마티스내과, 2예방의학교실

Received: September 10, 2015; Revised: October 14, 2015; Accepted: October 15, 2015

Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis

Ji-Won Kim1, Hwajeong Lee1, Jun Hyun Hwang2, Sung-Hoon Park1, Hye-Sun Lee1, Seong-Kyu Kim1, Jung-Yoon Choe1

1Division of Rheumatology, Department of Internal Medicine, 2Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea

Correspondence to:Jung-Yoon Choe
Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 42472, Korea. E-mail : jychoe@cu.ac.kr

Received: September 10, 2015; Revised: October 14, 2015; Accepted: October 15, 2015

Abstract

Objective. This study examined lung involvement in patients with rheumatoid arthritis (RA) and identified factors associated with airway disease (AD) and interstitial lung disease (ILD). Methods. A total of 507 RA patients were enrolled in a cross-sectional study. Lung involvement was assessed by high-resolution computed tomography scan. The patient groups were classified according to normal, AD, and ILD. Multinomial logistic regression analysis was performed to identify factors associated with AD and ILD. Results. The most frequent lung involvement was AD (38.3%) followed by ILD (12.6%). Old age (adjust odds ratio [aOR] 2.58, 95% confidence interval [CI] 1.70 to 3.90 for AD; aOR 4.38, 95% CI 2.30 to 8.35 for ILD), male gender (aOR 2.57, 95% CI 1.22 to 5.42 for AD; aOR 5.48, 95% CI 2.20 to 13.65 for ILD) were factors associated with AD and ILD in RA patients. ILD was associated with short disease duration (aOR 0.30, 95% CI 0.14 to 0.62), AD was associated with high titers of anti-cyclic citrullinated peptides antibodies (anti-CCP; aOR 1.61, 95% CI 1.07 to 2.44). Conclusion. AD was the most frequent lung involvement in patients with RA. Old age and male gender were both associated with AD and ILD. Short disease duration was associated with ILD. High titers of anti-CCP was associated with AD. (J Rheum Dis 2016;23:101-108)

Keywords: Rheumatoid arthritis, Obstructive lung diseases, Interstitial lung diseases, X-ray computed tomography, Risk factors

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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