J Rheum Dis 2016; 23(3): 141-147
Published online June 30, 2016
© Korean College of Rheumatology
Correspondence to : Ha-Jeong Kim, Department of Physiology, Kyungpook National University School of Medicine, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea. E-mail:kimhajeong@knu.ac.kr
This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Osteoclasts are a major component of bone metabolism in physiologic condition and in rheumatoid arthritis (RA). RA is a chronic, autoimmune, inflammatory disease primarily affecting the joints. Joint inflammation leads to cartilage and bone destruction by osteoclast activation. This osteoclast activation leads to typical RA symptoms and is the therapeutic target. Several kinds of drugs are used for preventing bone loss by osteoclasts in RA patients. However, the bone destructive action of osteoclasts is not the only mechanism in RA pathogenesis. Recent research suggests that the osteoclasts regulate hematopoietic stem cell niches and invoke immune responses in bone. Osteoclasts are derived from bone marrow hematopoietic stem cells, and maintain the hematopoietic stem cell niches contract with osteoblasts. Osteoclasts secret several cytokines to regulate inflammation and T cell differentiation, and present antigen to T cells via major histocompatibility complex class I and class II molecules. Osteoclast concepts in both origins and functions are under major reconsideration and research. In this review, we will discuss these new insights. (J Rheum Dis 2016;23:141-147)
Keywords Osteoclasts, Osteoclastogenesis, Rheumatoid arthritis, RANK ligand, Immunity
J Rheum Dis 2016; 23(3): 141-147
Published online June 30, 2016
Copyright © Korean College of Rheumatology.
Won-Ju Jeong1, Ha-Jeong Kim2
Departments of 1Orthopedic Surgery and 2Physiology, Kyungpook National University School of Medicine, Daegu, Korea
Correspondence to:Ha-Jeong Kim, Department of Physiology, Kyungpook National University School of Medicine, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea. E-mail:kimhajeong@knu.ac.kr
This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Osteoclasts are a major component of bone metabolism in physiologic condition and in rheumatoid arthritis (RA). RA is a chronic, autoimmune, inflammatory disease primarily affecting the joints. Joint inflammation leads to cartilage and bone destruction by osteoclast activation. This osteoclast activation leads to typical RA symptoms and is the therapeutic target. Several kinds of drugs are used for preventing bone loss by osteoclasts in RA patients. However, the bone destructive action of osteoclasts is not the only mechanism in RA pathogenesis. Recent research suggests that the osteoclasts regulate hematopoietic stem cell niches and invoke immune responses in bone. Osteoclasts are derived from bone marrow hematopoietic stem cells, and maintain the hematopoietic stem cell niches contract with osteoblasts. Osteoclasts secret several cytokines to regulate inflammation and T cell differentiation, and present antigen to T cells via major histocompatibility complex class I and class II molecules. Osteoclast concepts in both origins and functions are under major reconsideration and research. In this review, we will discuss these new insights. (J Rheum Dis 2016;23:141-147)
Keywords: Osteoclasts, Osteoclastogenesis, Rheumatoid arthritis, RANK ligand, Immunity
Yun Jung Choi, Wan-Hee Yoo
J Rheum Dis 2016; 23(4): 202-211Semun Seong, Jung Ha Kim, Nacksung Kim
J Rheum Dis 2016; 23(3): 148-153Yong-Geun Jeong, Hyun-Ok Kim, Hye Song Lim, Young-Sool Hah, Hee Young Cho, Jiahua Yu, Byung-Hyun Park, Gou Young Koh, Sang-Il Lee
J Rheum Dis 2012; 19(2): 82-90