Original Article

J Rheum Dis 2016; 23(5): 297-303

Published online October 31, 2016

© Korean College of Rheumatology

Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Expression in the Minor Salivary Glands of Sjögren’s Syndrome Patients

Kyung-Eun Lee1,*, Dong-Jin Park1,*, Sung-Eun Choi1, Ji-Hyoun Kang1, Yi-Rang Yim1, Ji-Eun Kim1, Jeong-Won Lee1, Lihui Wen1, Tae-Jong Kim1, Yong-Wook Park1, Ji Shin Lee2, Kyung Chul Yoon3, Shin-Seok Lee1

1Division of Rheumatology, Department of Internal Medicine, Departments of 2Pathology, 3Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea

Correspondence to : Shin-Seok Lee, Division of Rheumatology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Korea. E-mail:shinseok@chonnam.ac.kr
*These two authors contributed equally to this work.

Received: August 6, 2016; Revised: September 7, 2016; Accepted: September 21, 2016

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the laboratory and clinical manifestations of Sjögren’s syndrome (SS) association with chemokine (C-X-C motif) ligand 1 (CXCL1) expression in the ductal and acinar salivary gland epithelial cells (SGEC) of the minor salivary glands. Methods. The sociodemographic data of 106 SS patients was obtained, and the glandular and extraglandular manifestations of the disease documented. The minor salivary glands were biopsied and the laboratory findings analyzed. European League Against Rheumatism SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) scores were obtained during biopsy. An immunohistochemical approach was used to define the expression of CXCL1 in the salivary glands. Results. Of 106 patients, the minor salivary glands of 22 patients (20.7%) stained positively for CXCL1. Such CXCL1-positive patients exhibited higher ESSDAI scores at the time of biopsy than the CXCL1-negative patients (3.86±2.27 vs. 2.64±1.62, p=0.015). Lymphadenopathy was more frequently observed in CXCL1-positive patients, compared with CXCL1-negative patients (31.8% vs. 9.5%, p=0.014). No differences between groups were identified in terms of sociodemographic characteristics, laboratory data, or the extent of the glandular manifestation of SS. Conclusion. The expression of CXCL1 within the ductal and acinar SGEC of SS patients is associated with lymphadenopathy and elevated clinical disease activity. CXCL1 may play an important role in the disease activity and prognosis of SS.

Keywords Chemokines, CXCL1, Disease activity, Sjögren’s syndrome

Article

Original Article

J Rheum Dis 2016; 23(5): 297-303

Published online October 31, 2016 https://doi.org/10.4078/jrd.2016.23.5.297

Copyright © Korean College of Rheumatology.

Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Expression in the Minor Salivary Glands of Sjögren’s Syndrome Patients

Kyung-Eun Lee1,*, Dong-Jin Park1,*, Sung-Eun Choi1, Ji-Hyoun Kang1, Yi-Rang Yim1, Ji-Eun Kim1, Jeong-Won Lee1, Lihui Wen1, Tae-Jong Kim1, Yong-Wook Park1, Ji Shin Lee2, Kyung Chul Yoon3, Shin-Seok Lee1

1Division of Rheumatology, Department of Internal Medicine, Departments of 2Pathology, 3Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea

Correspondence to:Shin-Seok Lee, Division of Rheumatology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Korea. E-mail:shinseok@chonnam.ac.kr
*These two authors contributed equally to this work.

Received: August 6, 2016; Revised: September 7, 2016; Accepted: September 21, 2016

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the laboratory and clinical manifestations of Sjögren’s syndrome (SS) association with chemokine (C-X-C motif) ligand 1 (CXCL1) expression in the ductal and acinar salivary gland epithelial cells (SGEC) of the minor salivary glands. Methods. The sociodemographic data of 106 SS patients was obtained, and the glandular and extraglandular manifestations of the disease documented. The minor salivary glands were biopsied and the laboratory findings analyzed. European League Against Rheumatism SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) scores were obtained during biopsy. An immunohistochemical approach was used to define the expression of CXCL1 in the salivary glands. Results. Of 106 patients, the minor salivary glands of 22 patients (20.7%) stained positively for CXCL1. Such CXCL1-positive patients exhibited higher ESSDAI scores at the time of biopsy than the CXCL1-negative patients (3.86±2.27 vs. 2.64±1.62, p=0.015). Lymphadenopathy was more frequently observed in CXCL1-positive patients, compared with CXCL1-negative patients (31.8% vs. 9.5%, p=0.014). No differences between groups were identified in terms of sociodemographic characteristics, laboratory data, or the extent of the glandular manifestation of SS. Conclusion. The expression of CXCL1 within the ductal and acinar SGEC of SS patients is associated with lymphadenopathy and elevated clinical disease activity. CXCL1 may play an important role in the disease activity and prognosis of SS.

Keywords: Chemokines, CXCL1, Disease activity, Sjö,gren’s syndrome

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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