Case Report
J Rheum Dis 2017; 24(3): 157-160
Published online June 30, 2017
© Korean College of Rheumatology
A Case of Refractory Oral Aphthous Ulcer Successfully Treated with Adalimumab
Correspondence to : Yoon-Kyoung Sung, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
E-mail：sungyk@hanyang.ac.kr
This is an Open Access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Oral aphthous ulcer is a common lesion characterized by loss of dermal tissue of various shapes in many diseases. It is not serious, but may affect quality of life through pain and discomfort. In many cases, it heals spontaneously without treatment or with topical agents such as antiseptics, analgesics and corticosteroid in a few days. However, rarely, there are a few cases of aphthous ulcer that remain refractory despite appropriate treatment. Tumor necrosis factor-α inhibitors have recently been used in treatment of severe mucosal ulcer in Behçet’s disease. Herein, we report a patient suffering from refractory oral aphthous ulcers that were resistant to topical and systemic agents, but were successfully treated with adalimumab.
Keywords Oral ulcer, Aphthous stomatitis, Tumor necrosis factor-alpha inhibitor, Adalimumab
PDF
Standard view
Export citation
Share Article
Case Report
J Rheum Dis 2017; 24(3): 157-160
Published online June 30, 2017 https://doi.org/10.4078/jrd.2017.24.3.157
Copyright © Korean College of Rheumatology.
A Case of Refractory Oral Aphthous Ulcer Successfully Treated with Adalimumab
Jinyeong Kim1, Myung-jin Song1, Hye-Jin Jeong2, Soo-Kyung Cho1,3, Yoon-Kyoung Sung1,3
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, 2Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea
Correspondence to:Yoon-Kyoung Sung, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
E-mail：sungyk@hanyang.ac.kr
This is an Open Access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Oral aphthous ulcer is a common lesion characterized by loss of dermal tissue of various shapes in many diseases. It is not serious, but may affect quality of life through pain and discomfort. In many cases, it heals spontaneously without treatment or with topical agents such as antiseptics, analgesics and corticosteroid in a few days. However, rarely, there are a few cases of aphthous ulcer that remain refractory despite appropriate treatment. Tumor necrosis factor-α inhibitors have recently been used in treatment of severe mucosal ulcer in Behçet’s disease. Herein, we report a patient suffering from refractory oral aphthous ulcers that were resistant to topical and systemic agents, but were successfully treated with adalimumab.
Keywords: Oral ulcer, Aphthous stomatitis, Tumor necrosis factor-alpha inhibitor, Adalimumab
Article Tools
Stats or Metrics
Share this article on
Related articles in JRD
-
Corticosteroid-free adalimumab-cyclophosphamide combination therapy for acute phase neuro-Behçet’s disease: a case report
Ji Hyoun Kim, M.D., Sang Wan Chung, M.D., Ph.D., Yun Jong Lee, M.D., Ph.D.
J Rheum Dis 2024; 31(3): 178-181 -
Health-related Quality of Life Outcomes of Adalimumab for Patients With Rheumatoid Arthritis in Korea
Myeung-su Lee, M.D., Ph.D., Chang Hoon Lee, M.D., Ph.D., Hye Soon Lee, M.D., Ph.D., Yoon-Kyoung Sung, M.D., Ph.D., Jung Ran Choi, M.D., Ph.D., Kyungsu Park, M.D., Ph.D., Mi-Kyoung Lim, M.D., Ph.D., Byoong Yong Choi, M.D., Hyoun-Ah Kim, M.D., Ph.D., Seung Won Choi, M.D., Ph.D., Yusun Lee, M.D., Wan-Hee Yoo, M.D., Ph.D.
J Rheum Dis 2021; 28(2): 68-75 -
Successful Treatment of Refractory Cutaneous Polyarteritis Nodosa with Adalimumab
Eunyoung Ahn, Min Wook So
J Rheum Dis 2018; 25(4): 302-305
