Original

The Journal of the Korean Rheumatism Association 2003; 10(1): 16-22

Published online March 30, 2003

© Korean College of Rheumatology

루푸스에서 유리형 Fas는 질병의 활성도를 반영하는가?

김윤아·이신석*·박미정*

서남대학교 의과대학 내과학교실, 전남대학교 의과대학 내과학교실*

Do Increased Levels of Soluble Fas Correlate with Disease Activity in Systemic Lupus Erythematosus?

Yun-A Kim, M.D., Shin-Seok Lee, M.D.*, Mi-Jeong Park, M.D.*

Department of Internal Medicine, Seonam University College of Medicine, Gwangju Department of Internal Medicine*, Chonnam National University Medical School, Gwangju, Korea

Correspondence to : Shin-Seok Lee

Abstract

Objective: To determine whether levels of soluble Fas (sFas) are elevated in patients with systemic lupus erythematosus (SLE) and correlated with clinical disease activity.

Methods: Serum samples were obtained from 62 SLE patients and 39 normal controls. We measured sFas levels using an enzyme-linked immunosorbent assay. Disease activity variables including Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were examined. Results: The mean age of the patients was 32.1 years (range 13∼60 years) and the mean disease duration was 3.0 years (range 0.2∼10.0 years); 1 patient was male (1.6%). The median serum sFas concentration was 610.0 pg/ml for SLE patients and 292.9 pg/ml in controls. The serum sFas concentration was significantly higher in SLE patients than in controls (p<0.001). The Receiver Operating Characteristics (ROC) curve showed that the area under the curve for sFas was 0.911. Using the cut-off value of 370.5 pg/ml, the sensitivity was 0.871 and the specificity was 0.846. However, we could not find any correlation between sFas levels and disease activity variables such as SLEDAI, complement, and anti-dsDNA antibodies. There was no significant difference in sFas levels between active (SLEDAI ≥8) and inactive (SLEDAI <8) SLE patients. Conclusion: These results suggest that sFas levels are elevated in SLE patients, but sFas does not reflect disease activity.

Keywords Systemic lupus erythematosus, Soluble Fas, Disease activity

Article

Original

The Journal of the Korean Rheumatism Association 2003; 10(1): 16-22

Published online March 30, 2003

Copyright © Korean College of Rheumatology.

루푸스에서 유리형 Fas는 질병의 활성도를 반영하는가?

김윤아·이신석*·박미정*

서남대학교 의과대학 내과학교실, 전남대학교 의과대학 내과학교실*

Do Increased Levels of Soluble Fas Correlate with Disease Activity in Systemic Lupus Erythematosus?

Yun-A Kim, M.D., Shin-Seok Lee, M.D.*, Mi-Jeong Park, M.D.*

Department of Internal Medicine, Seonam University College of Medicine, Gwangju Department of Internal Medicine*, Chonnam National University Medical School, Gwangju, Korea

Correspondence to:Shin-Seok Lee

Abstract

Objective: To determine whether levels of soluble Fas (sFas) are elevated in patients with systemic lupus erythematosus (SLE) and correlated with clinical disease activity.

Methods: Serum samples were obtained from 62 SLE patients and 39 normal controls. We measured sFas levels using an enzyme-linked immunosorbent assay. Disease activity variables including Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were examined. Results: The mean age of the patients was 32.1 years (range 13∼60 years) and the mean disease duration was 3.0 years (range 0.2∼10.0 years); 1 patient was male (1.6%). The median serum sFas concentration was 610.0 pg/ml for SLE patients and 292.9 pg/ml in controls. The serum sFas concentration was significantly higher in SLE patients than in controls (p<0.001). The Receiver Operating Characteristics (ROC) curve showed that the area under the curve for sFas was 0.911. Using the cut-off value of 370.5 pg/ml, the sensitivity was 0.871 and the specificity was 0.846. However, we could not find any correlation between sFas levels and disease activity variables such as SLEDAI, complement, and anti-dsDNA antibodies. There was no significant difference in sFas levels between active (SLEDAI ≥8) and inactive (SLEDAI <8) SLE patients. Conclusion: These results suggest that sFas levels are elevated in SLE patients, but sFas does not reflect disease activity.

Keywords: Systemic lupus erythematosus, Soluble Fas, Disease activity

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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