The Journal of the Korean Rheumatism Association 2003; 10(3): 310-314
Published online September 30, 2003
© Korean College of Rheumatology
이원기·박용범*·정현주**·이수곤*
관동대학교 의과대학 내과학교실, 연세대학교 의과대학 내과학교실*, 병리학교실**
Correspondence to : Soo Kon Lee
We report a case of microscopic polyangiitis in a 52-year-old woman combined with systemic sclerosis. She was diagnosed as having limited systemic sclerosis based on symmetric skin thickening of fingers and distal arms, loss of substance from the finger pad, and bibasilar pulmonary fibrosis. Laboratory investigations showed positive antitopoisomerase I antibody. Subsequent evaluation revealed proteinuria and hematuria. Her serum creatinine concentration was elevated with detoriorated glomerular filtration. Serum antimyeloperoxidase antibody was strongly positive. A sural nerve biopsy revealed axonopathy due to early manifestations of vasculitis. Percutaneous renal biopsy showed focal necrotizing glomerulonephritis. Her renal function recovered with immunosuppressive therapy with high dose prednisolone and oral cyclophosphamide.
Keywords Systemic sclerosis, Microscopic polyangiitis
The Journal of the Korean Rheumatism Association 2003; 10(3): 310-314
Published online September 30, 2003
Copyright © Korean College of Rheumatology.
이원기·박용범*·정현주**·이수곤*
관동대학교 의과대학 내과학교실, 연세대학교 의과대학 내과학교실*, 병리학교실**
Won Ki Lee, M.D., Yong Beom Park, M.D.*, Hyeon Joo Jeong, M.D.**, Soo Kon Lee, M.D.*
Department of Internal Medicine, Myongji Hospital, Kwandong University College of Medicine, Gyunggi-do, Korea, Departments of Internal Medicine*, Pathology**, Yonsei University College of Medicine, Seoul, Korea
Correspondence to:Soo Kon Lee
We report a case of microscopic polyangiitis in a 52-year-old woman combined with systemic sclerosis. She was diagnosed as having limited systemic sclerosis based on symmetric skin thickening of fingers and distal arms, loss of substance from the finger pad, and bibasilar pulmonary fibrosis. Laboratory investigations showed positive antitopoisomerase I antibody. Subsequent evaluation revealed proteinuria and hematuria. Her serum creatinine concentration was elevated with detoriorated glomerular filtration. Serum antimyeloperoxidase antibody was strongly positive. A sural nerve biopsy revealed axonopathy due to early manifestations of vasculitis. Percutaneous renal biopsy showed focal necrotizing glomerulonephritis. Her renal function recovered with immunosuppressive therapy with high dose prednisolone and oral cyclophosphamide.
Keywords: Systemic sclerosis, Microscopic polyangiitis
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