Case

The Journal of the Korean Rheumatism Association 2003; 10(3): 310-314

Published online September 30, 2003

© Korean College of Rheumatology

제한형 전신피부경화증에 병발한 현미경적 다발혈관염

이원기·박용범*·정현주**·이수곤*

관동대학교 의과대학 내과학교실, 연세대학교 의과대학 내과학교실*, 병리학교실**

A Case of Microscopic Polyangiitis Combined with Limited Systemic Sclerosis

Won Ki Lee, M.D., Yong Beom Park, M.D.*, Hyeon Joo Jeong, M.D.**, Soo Kon Lee, M.D.*

Department of Internal Medicine, Myongji Hospital, Kwandong University College of Medicine, Gyunggi-do, Korea, Departments of Internal Medicine*, Pathology**, Yonsei University College of Medicine, Seoul, Korea

Correspondence to : Soo Kon Lee

Abstract

We report a case of microscopic polyangiitis in a 52-year-old woman combined with systemic sclerosis. She was diagnosed as having limited systemic sclerosis based on symmetric skin thickening of fingers and distal arms, loss of substance from the finger pad, and bibasilar pulmonary fibrosis. Laboratory investigations showed positive antitopoisomerase I antibody. Subsequent evaluation revealed proteinuria and hematuria. Her serum creatinine concentration was elevated with detoriorated glomerular filtration. Serum antimyeloperoxidase antibody was strongly positive. A sural nerve biopsy revealed axonopathy due to early manifestations of vasculitis. Percutaneous renal biopsy showed focal necrotizing glomerulonephritis. Her renal function recovered with immunosuppressive therapy with high dose prednisolone and oral cyclophosphamide.

Keywords Systemic sclerosis, Microscopic polyangiitis

Article

Case

The Journal of the Korean Rheumatism Association 2003; 10(3): 310-314

Published online September 30, 2003

Copyright © Korean College of Rheumatology.

제한형 전신피부경화증에 병발한 현미경적 다발혈관염

이원기·박용범*·정현주**·이수곤*

관동대학교 의과대학 내과학교실, 연세대학교 의과대학 내과학교실*, 병리학교실**

A Case of Microscopic Polyangiitis Combined with Limited Systemic Sclerosis

Won Ki Lee, M.D., Yong Beom Park, M.D.*, Hyeon Joo Jeong, M.D.**, Soo Kon Lee, M.D.*

Department of Internal Medicine, Myongji Hospital, Kwandong University College of Medicine, Gyunggi-do, Korea, Departments of Internal Medicine*, Pathology**, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:Soo Kon Lee

Abstract

We report a case of microscopic polyangiitis in a 52-year-old woman combined with systemic sclerosis. She was diagnosed as having limited systemic sclerosis based on symmetric skin thickening of fingers and distal arms, loss of substance from the finger pad, and bibasilar pulmonary fibrosis. Laboratory investigations showed positive antitopoisomerase I antibody. Subsequent evaluation revealed proteinuria and hematuria. Her serum creatinine concentration was elevated with detoriorated glomerular filtration. Serum antimyeloperoxidase antibody was strongly positive. A sural nerve biopsy revealed axonopathy due to early manifestations of vasculitis. Percutaneous renal biopsy showed focal necrotizing glomerulonephritis. Her renal function recovered with immunosuppressive therapy with high dose prednisolone and oral cyclophosphamide.

Keywords: Systemic sclerosis, Microscopic polyangiitis

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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