Original Article

The Journal of the Korean Rheumatism Association 2004; 11(4): 342-348

Published online December 30, 2004

© Korean College of Rheumatology

강직성 척추염 환자에서 골밀도 측정의 임상적 의의

왕준광·박의순·이혜순·엄완식·김태환·배상철·유대현·안유헌*·최윤영**·주경빈***·전재범

한양대학교 의과대학 내과학교실, 류마티스병원, 종합검진센터*, 핵의학교실**, 진단방사선과***

The Clinical Significance of Bone Mineral Density Measurement in Patients with Ankylosing Spondylitis

Joon-Kwang Wang, M.D., Ui-Soon Park, M.D., Hye-Soon Lee, M.D., Wan-Sik Uhm, M.D., Tae-Hwan Kim, M.D., Sang-Cheol Bae, M.D., Dae-Hyun Yoo, M.D., You-Hern Ahn, M.D.*, Yun-Young Choi, M.D.**, Kyung-Bin Joo, M.D.***, Jae-Bum Jun, M.D.

Department of Internal Medicine, The Hospital for Rheumatic Diseases, Health Promotion Center*, Department of Nuclear Medicine**, Department of Radiology***, Hanyang University, Seoul, Korea

Correspondence to : Jae-Bum Jun, M.D.

Abstract

Objective: Decrease in bone mineral density (BMD) occurs relatively early and is known to be correlated with disease activity in patients with ankylosing spondylitis (AS). We investigated BMD and its correlation factors in Korean patients with AS. Methods: Fifty patients with AS fulfilling modified New York criteria and age-, sex-, and body mass index-matched 100 normal controls were selected. Medical records were reviewed retrospectively. Lumbar and femur BMD was measured using a dual energy X-ray absorptiometry. Results: Both lumbar and femur BMD in patients with AS were significantly lower than BMD in control group. Although Bath ankylosing spondylitis disease activity index, C-reactive protein and erythrocyte sedimentation rate showed no correlation with BMD, lumbar BMD in patients with high disease activity in terms of inflammatory factors was significantly lower than that in patients with low disease activity. Conclusion: BMD in patients with AS was significantly lower than those in control group. Early detection and appropriate management will be necessary in patients with AS.

Keywords Ankylosing spondylitis, Bone mineral density

Article

Original Article

The Journal of the Korean Rheumatism Association 2004; 11(4): 342-348

Published online December 30, 2004

Copyright © Korean College of Rheumatology.

강직성 척추염 환자에서 골밀도 측정의 임상적 의의

왕준광·박의순·이혜순·엄완식·김태환·배상철·유대현·안유헌*·최윤영**·주경빈***·전재범

한양대학교 의과대학 내과학교실, 류마티스병원, 종합검진센터*, 핵의학교실**, 진단방사선과***

The Clinical Significance of Bone Mineral Density Measurement in Patients with Ankylosing Spondylitis

Joon-Kwang Wang, M.D., Ui-Soon Park, M.D., Hye-Soon Lee, M.D., Wan-Sik Uhm, M.D., Tae-Hwan Kim, M.D., Sang-Cheol Bae, M.D., Dae-Hyun Yoo, M.D., You-Hern Ahn, M.D.*, Yun-Young Choi, M.D.**, Kyung-Bin Joo, M.D.***, Jae-Bum Jun, M.D.

Department of Internal Medicine, The Hospital for Rheumatic Diseases, Health Promotion Center*, Department of Nuclear Medicine**, Department of Radiology***, Hanyang University, Seoul, Korea

Correspondence to:Jae-Bum Jun, M.D.

Abstract

Objective: Decrease in bone mineral density (BMD) occurs relatively early and is known to be correlated with disease activity in patients with ankylosing spondylitis (AS). We investigated BMD and its correlation factors in Korean patients with AS. Methods: Fifty patients with AS fulfilling modified New York criteria and age-, sex-, and body mass index-matched 100 normal controls were selected. Medical records were reviewed retrospectively. Lumbar and femur BMD was measured using a dual energy X-ray absorptiometry. Results: Both lumbar and femur BMD in patients with AS were significantly lower than BMD in control group. Although Bath ankylosing spondylitis disease activity index, C-reactive protein and erythrocyte sedimentation rate showed no correlation with BMD, lumbar BMD in patients with high disease activity in terms of inflammatory factors was significantly lower than that in patients with low disease activity. Conclusion: BMD in patients with AS was significantly lower than those in control group. Early detection and appropriate management will be necessary in patients with AS.

Keywords: Ankylosing spondylitis, Bone mineral density

JRD
Oct 01, 2024 Vol.31 No.4, pp. 191~263
COVER PICTURE
Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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