Original

The Journal of the Korean Rheumatism Association 2005; 12(4): 304-310

Published online December 30, 2005

© Korean College of Rheumatology

S 단백 활성도 감소가 베체트병의 질병 활동도를 반영한다

권성렬·임미진·박신구*·하기철·기성호·박보형·문연숙**·박원

인하대학교 의과대학 내과학교실, 산업의학교실*, 진단검사의학교실**

Decreased Protein S Activity Related to the Disease Activity of Behçet's Disease

Seong Ryul Kwon, M.D., Mie Jin Lim, M.D., Shin Goo Park, M.D.*, Ki Cheol Ha, M.D., Sung Ho Ki, M.D., Bo Hyoung Park, M.D., Yeon Sook Moon, M.D.**, Won Park, M.D.

Departments of Internal Medicine, Occupational & Environmental Medicine*, and Laboratory Medicine**, Inha University College of Medicine, Incheon, Korea

Correspondence to : Won Park

Abstract

Objective: To see whether the active inflammation in Behçet's disease (BD) can cause thrombotic disorders by decreasing the protein S activity (PSA), we evaluated the relationship between PSA decrease and disease activity of BD. Methods: We included 122 patients with BD whose PSAs were measured between August 1998 and April 2005. In 51 BD patients, the PSA was measured again when there were changes in the number of items of "The Behcet's Disease Current Activity Form (BDCAF)". Results: Thrombosis rate was 2.5% (3/122), and the PSA was low in all 3 of the patients. The incidence of low PSA in total 122 BD patients was 27% (33/122). The incidence of low PSA in active BD patients was 33.7% (31/92), and it was significantly more frequent in active BD patients than in inactive patients, 6.7% (2/30) (χ2-test, p value=0.0038). The decrease of PSA had good correlation with the number of BDCAF items (r=⁣0.351, p=0.012). Conclusion: The PSA decrease is related to the disease activity of BD. PSA could be not only the risk factor for thrombotic disorder but also the activity marker for the BD and other inflammatory diseases.

Keywords Behçet's disease, Disease activity, Protein S activity, Thrombosis

Article

Original

The Journal of the Korean Rheumatism Association 2005; 12(4): 304-310

Published online December 30, 2005

Copyright © Korean College of Rheumatology.

S 단백 활성도 감소가 베체트병의 질병 활동도를 반영한다

권성렬·임미진·박신구*·하기철·기성호·박보형·문연숙**·박원

인하대학교 의과대학 내과학교실, 산업의학교실*, 진단검사의학교실**

Decreased Protein S Activity Related to the Disease Activity of Behçet's Disease

Seong Ryul Kwon, M.D., Mie Jin Lim, M.D., Shin Goo Park, M.D.*, Ki Cheol Ha, M.D., Sung Ho Ki, M.D., Bo Hyoung Park, M.D., Yeon Sook Moon, M.D.**, Won Park, M.D.

Departments of Internal Medicine, Occupational & Environmental Medicine*, and Laboratory Medicine**, Inha University College of Medicine, Incheon, Korea

Correspondence to:Won Park

Abstract

Objective: To see whether the active inflammation in Behçet's disease (BD) can cause thrombotic disorders by decreasing the protein S activity (PSA), we evaluated the relationship between PSA decrease and disease activity of BD. Methods: We included 122 patients with BD whose PSAs were measured between August 1998 and April 2005. In 51 BD patients, the PSA was measured again when there were changes in the number of items of "The Behcet's Disease Current Activity Form (BDCAF)". Results: Thrombosis rate was 2.5% (3/122), and the PSA was low in all 3 of the patients. The incidence of low PSA in total 122 BD patients was 27% (33/122). The incidence of low PSA in active BD patients was 33.7% (31/92), and it was significantly more frequent in active BD patients than in inactive patients, 6.7% (2/30) (χ2-test, p value=0.0038). The decrease of PSA had good correlation with the number of BDCAF items (r=⁣0.351, p=0.012). Conclusion: The PSA decrease is related to the disease activity of BD. PSA could be not only the risk factor for thrombotic disorder but also the activity marker for the BD and other inflammatory diseases.

Keywords: Behç,et's disease, Disease activity, Protein S activity, Thrombosis

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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