Case Report

The Journal of the Korean Rheumatism Association 2006; 13(2): 166-170

Published online June 30, 2006

© Korean College of Rheumatology

폐암과 병발한 류마티스 관절염 환자에서 항암요법에 따른 임상경과

최선욱·정재규·형복진·박상미·정현정·박보형·심병용·김완욱·김훈교

가톨릭대학교 의과대학 성빈센트병원 내과

A Case of Patient with Coincident Lung Cancer and Rheumatoid Arthritis Treated with Docetaxel-Cisplatin Chemotherapy

Son-Ook Choi, M.D., Jae-Gu Jung, M.D., Bok Jin Hyoung, M.D., Sang-Mi Park, M.D., Hyun Jung Jung, M.D., Bo Hyoung Park, M.D., Byoung-Yong Shim, M.D., Wan-Uk Kim, M.D., Hoon-Kyo Kim, M.D.

Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea

Correspondence to : Hoon-Kyo Kim

Abstract

A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxychloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.

Keywords Lung cancer, Rheumatoid arthritis, Chemotherapy, Docetaxel

Article

Case Report

The Journal of the Korean Rheumatism Association 2006; 13(2): 166-170

Published online June 30, 2006

Copyright © Korean College of Rheumatology.

폐암과 병발한 류마티스 관절염 환자에서 항암요법에 따른 임상경과

최선욱·정재규·형복진·박상미·정현정·박보형·심병용·김완욱·김훈교

가톨릭대학교 의과대학 성빈센트병원 내과

A Case of Patient with Coincident Lung Cancer and Rheumatoid Arthritis Treated with Docetaxel-Cisplatin Chemotherapy

Son-Ook Choi, M.D., Jae-Gu Jung, M.D., Bok Jin Hyoung, M.D., Sang-Mi Park, M.D., Hyun Jung Jung, M.D., Bo Hyoung Park, M.D., Byoung-Yong Shim, M.D., Wan-Uk Kim, M.D., Hoon-Kyo Kim, M.D.

Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea

Correspondence to:Hoon-Kyo Kim

Abstract

A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxychloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.

Keywords: Lung cancer, Rheumatoid arthritis, Chemotherapy, Docetaxel

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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