The Journal of the Korean Rheumatism Association 2006; 13(2): 166-170
Published online June 30, 2006
© Korean College of Rheumatology
최선욱·정재규·형복진·박상미·정현정·박보형·심병용·김완욱·김훈교
가톨릭대학교 의과대학 성빈센트병원 내과
Correspondence to : Hoon-Kyo Kim
A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxychloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.
Keywords Lung cancer, Rheumatoid arthritis, Chemotherapy, Docetaxel
The Journal of the Korean Rheumatism Association 2006; 13(2): 166-170
Published online June 30, 2006
Copyright © Korean College of Rheumatology.
최선욱·정재규·형복진·박상미·정현정·박보형·심병용·김완욱·김훈교
가톨릭대학교 의과대학 성빈센트병원 내과
Son-Ook Choi, M.D., Jae-Gu Jung, M.D., Bok Jin Hyoung, M.D., Sang-Mi Park, M.D., Hyun Jung Jung, M.D., Bo Hyoung Park, M.D., Byoung-Yong Shim, M.D., Wan-Uk Kim, M.D., Hoon-Kyo Kim, M.D.
Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea
Correspondence to:Hoon-Kyo Kim
A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxychloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.
Keywords: Lung cancer, Rheumatoid arthritis, Chemotherapy, Docetaxel
Jae-Hyung Nam, Jong-Joo Moon, June-Hyuk Lee, Sung-Woo Park, An-Soo Jang, Do-Jin Kim, Chan Hong Jeon, Eun-Suk Koh
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