Original

The Journal of the Korean Rheumatism Association 2006; 13(4): 272-278

Published online December 30, 2006

© Korean College of Rheumatology

류마티스관절염에서 치료 시기가 질병 활성도 및 관절 손상에 미치는 영향

길지훈·정세진·최상태·강은진·이상원·박민찬·박용범·이수곤

연세대학교 의과대학 내과학교실

The Effect of Early Diagnosis and Treatment on the Disease Activity and Joint Damages in Korean Patients with Rheumatoid Arthritis

Jee Hoon Ghil, M.D., Se Jin Jung, M.D., Sang Tae Choi, M.D., Eun Jin Kang, M.D., Sang Won Lee, M.D., Min Chan Park, M.D., Yong Beom Park, M.D., Soo Kon Lee, M.D.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Correspondence to : Soo Kon Lee

Abstract

Objective: We investigated the effect of the early diagnosis and treatment on the disease activity and joint damage in patients with rheumatoid arthritis (RA). Methods: We enrolled 242 RA patients (male 50 patients, female 192 patients, mean age 49.7⁑13.5 years old) in this study. They were divided into two groups according to lag-time to diagnose RA from the onset of symptoms. 136 RA patients whose lag-time did not exceed 12 months were classified into early diagnosed RA group and 106 RA patients whose lag-time over 12 months were classified into delayed diagnosed RA group. Baseline date were assessed at the time of diagnosis. Disease activity was assessed by sums of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) during first year after diagnosis. Radiological joint damages were evaluated using modified Sharp score. Results: At the time of diagnosis, the age of patients, ESR and platelet counts were significantly decreased, and hemoglobin level was significantly increased in early diagnosed RA group. Early diagnosed RA group showed lower sums of ESR and CRP than delayed diagnosed RA group significantly. Modified sharp score at the time of diagnosis and after treatment were significantly lower in early diagnosed RA group than delayed diagnosed RA group. The difference of modified sharp score between at the time of diagnosis and after treatment were lower in early diagnosed RA group than delayed diagnosed RA group too. Conclusion: The early diagnosis and treatment of RA reduced extent of joint damage and provoked better response to treatment significantly.

Keywords Rheumatoid arthritis, Early diagnosis, Early treatment, Prognosis

Article

Original

The Journal of the Korean Rheumatism Association 2006; 13(4): 272-278

Published online December 30, 2006

Copyright © Korean College of Rheumatology.

류마티스관절염에서 치료 시기가 질병 활성도 및 관절 손상에 미치는 영향

길지훈·정세진·최상태·강은진·이상원·박민찬·박용범·이수곤

연세대학교 의과대학 내과학교실

The Effect of Early Diagnosis and Treatment on the Disease Activity and Joint Damages in Korean Patients with Rheumatoid Arthritis

Jee Hoon Ghil, M.D., Se Jin Jung, M.D., Sang Tae Choi, M.D., Eun Jin Kang, M.D., Sang Won Lee, M.D., Min Chan Park, M.D., Yong Beom Park, M.D., Soo Kon Lee, M.D.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:Soo Kon Lee

Abstract

Objective: We investigated the effect of the early diagnosis and treatment on the disease activity and joint damage in patients with rheumatoid arthritis (RA). Methods: We enrolled 242 RA patients (male 50 patients, female 192 patients, mean age 49.7⁑13.5 years old) in this study. They were divided into two groups according to lag-time to diagnose RA from the onset of symptoms. 136 RA patients whose lag-time did not exceed 12 months were classified into early diagnosed RA group and 106 RA patients whose lag-time over 12 months were classified into delayed diagnosed RA group. Baseline date were assessed at the time of diagnosis. Disease activity was assessed by sums of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) during first year after diagnosis. Radiological joint damages were evaluated using modified Sharp score. Results: At the time of diagnosis, the age of patients, ESR and platelet counts were significantly decreased, and hemoglobin level was significantly increased in early diagnosed RA group. Early diagnosed RA group showed lower sums of ESR and CRP than delayed diagnosed RA group significantly. Modified sharp score at the time of diagnosis and after treatment were significantly lower in early diagnosed RA group than delayed diagnosed RA group. The difference of modified sharp score between at the time of diagnosis and after treatment were lower in early diagnosed RA group than delayed diagnosed RA group too. Conclusion: The early diagnosis and treatment of RA reduced extent of joint damage and provoked better response to treatment significantly.

Keywords: Rheumatoid arthritis, Early diagnosis, Early treatment, Prognosis

JRD
Oct 01, 2024 Vol.31 No.4, pp. 191~263
COVER PICTURE
Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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