The Journal of the Korean Rheumatism Association 2006; 13(4): 285-290
Published online December 30, 2006
© Korean College of Rheumatology
허지안·서수홍·박성환·조철수·김호연
가톨릭대학교 의과대학 내과학교실
Correspondence to : Sung-Hwan Park
oncordance rate between tuberculin skin test (TST) and T-SPOT.TB (T-SPOT) for detecting latent tuberculosis in patients with rheumatoid arthritis (RA) received disease modifying antirheumatic drugs (DMARDs) and/or immunosuppressant. Methods: Fifty four patients with RA refractory to conventional DMARDs and planned ahead to be received tumor necrosis factor-α (TNF-α) blockade were enrolled in this study. The TST was performed by Mantoux method. Over 10 mm induration size was considered to be positive in the TST. The peripheral blood were collected from all patients and used for the T-SPOT. Results: Only six patients (11.11%) had a positive TST, and 48 patients (88.89%) had a negative TST. The mean TST values were 13.51⁑3.51 mm (range: 10∼19 mm) in TST () group and 2.50⁑3.12 mm (range: 0∼9 mm) in TST () group, respectively. T-SPOT was indeterminate in 7 patients (12.96%). Twenty-five patients (53.19%) had a positive result, and 22 patients (46.81%) had a negative result in 47 patients determinated with T-SPOT. There was poor overall agreement between results of TST and T-SPOT (p=0.194). Conclusion: There was no concordance between TST and T-SPOT in patients with RA received DMARDs and/or immunosuppressant. Therefore, the results of TST should be interpreted with caution, taking into consideration of the result of T-SPOT in patients with RA who are prone to having false negative of TST.
Keywords Tuberculin skin test, T-SPOT.TB, Latent M. tuberculosis infection, Rheumatoid arthritis
The Journal of the Korean Rheumatism Association 2006; 13(4): 285-290
Published online December 30, 2006
Copyright © Korean College of Rheumatology.
허지안·서수홍·박성환·조철수·김호연
가톨릭대학교 의과대학 내과학교실
Ji-An Hur, M.D., Soo-Hong Seo, M.D., Sung-Hwan Park, M.D., Chul-Soo Cho, M.D., Ho-Youn Kim, M.D.
Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
Objective: To evaluate c
Correspondence to:Sung-Hwan Park
oncordance rate between tuberculin skin test (TST) and T-SPOT.TB (T-SPOT) for detecting latent tuberculosis in patients with rheumatoid arthritis (RA) received disease modifying antirheumatic drugs (DMARDs) and/or immunosuppressant. Methods: Fifty four patients with RA refractory to conventional DMARDs and planned ahead to be received tumor necrosis factor-α (TNF-α) blockade were enrolled in this study. The TST was performed by Mantoux method. Over 10 mm induration size was considered to be positive in the TST. The peripheral blood were collected from all patients and used for the T-SPOT. Results: Only six patients (11.11%) had a positive TST, and 48 patients (88.89%) had a negative TST. The mean TST values were 13.51⁑3.51 mm (range: 10∼19 mm) in TST () group and 2.50⁑3.12 mm (range: 0∼9 mm) in TST () group, respectively. T-SPOT was indeterminate in 7 patients (12.96%). Twenty-five patients (53.19%) had a positive result, and 22 patients (46.81%) had a negative result in 47 patients determinated with T-SPOT. There was poor overall agreement between results of TST and T-SPOT (p=0.194). Conclusion: There was no concordance between TST and T-SPOT in patients with RA received DMARDs and/or immunosuppressant. Therefore, the results of TST should be interpreted with caution, taking into consideration of the result of T-SPOT in patients with RA who are prone to having false negative of TST.
Keywords: Tuberculin skin test, T-SPOT.TB, Latent M. tuberculosis infection, Rheumatoid arthritis
Byeongzu Ghang, M.D., Ph.D., Jin Kyun Park, M.D., Ph.D., Ji Hyeon Ju, M.D., Ph.D., Seungwoo Han, M.D., Ph.D.
J Rheum Dis -0001; ():Shohei Anno, M.D., Kentaro Inui, M.D., Ph.D., Masahiro Tada, M.D., Ph.D., Yuko Sugioka, M.D., Ph.D., Tadashi Okano, M.D., Ph.D.,, Kenji Mamoto, M.D., Ph.D., Tatsuya Koike, M.D., Ph.D.
J Rheum Dis -0001; ():Soo Min Ahn, M.D., Ph.D., Seonok Kim, MSc., Ye-Jee Kim, Ph.D., Seokchan Hong, M.D., Ph.D., Chang-Keun Lee, M.D., Ph.D., Bin Yoo, M.D., Ph.D., Ji Seon Oh, M.D., Ph.D., Yong-Gil Kim, M.D., Ph.D.
J Rheum Dis -0001; ():