Original

The Journal of the Korean Rheumatism Association 2006; 13(4): 285-290

Published online December 30, 2006

© Korean College of Rheumatology

류마티스관절염 환자에서 잠복결핵 진단을 위한 투베르쿨린 검사와 T-SPOT.TB 사이의 일치율에 관한 연구

허지안·서수홍·박성환·조철수·김호연

가톨릭대학교 의과대학 내과학교실

Discrepancy between the Tuberculin Skin Test and the T-SPOT.TB for Detecting Latent Mycobacterium tuberculosis Infection in Patients with Rheumatoid Arthritis

Ji-An Hur, M.D., Soo-Hong Seo, M.D., Sung-Hwan Park, M.D., Chul-Soo Cho, M.D., Ho-Youn Kim, M.D.

Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
Objective: To evaluate c

Correspondence to : Sung-Hwan Park

Abstract

oncordance rate between tuberculin skin test (TST) and T-SPOT.TB (T-SPOT) for detecting latent tuberculosis in patients with rheumatoid arthritis (RA) received disease modifying antirheumatic drugs (DMARDs) and/or immunosuppressant. Methods: Fifty four patients with RA refractory to conventional DMARDs and planned ahead to be received tumor necrosis factor-α (TNF-α) blockade were enrolled in this study. The TST was performed by Mantoux method. Over 10 mm induration size was considered to be positive in the TST. The peripheral blood were collected from all patients and used for the T-SPOT. Results: Only six patients (11.11%) had a positive TST, and 48 patients (88.89%) had a negative TST. The mean TST values were 13.51⁑3.51 mm (range: 10∼19 mm) in TST (⁢) group and 2.50⁑3.12 mm (range: 0∼9 mm) in TST (⁣) group, respectively. T-SPOT was indeterminate in 7 patients (12.96%). Twenty-five patients (53.19%) had a positive result, and 22 patients (46.81%) had a negative result in 47 patients determinated with T-SPOT. There was poor overall agreement between results of TST and T-SPOT (p=0.194). Conclusion: There was no concordance between TST and T-SPOT in patients with RA received DMARDs and/or immunosuppressant. Therefore, the results of TST should be interpreted with caution, taking into consideration of the result of T-SPOT in patients with RA who are prone to having false negative of TST.

Keywords Tuberculin skin test, T-SPOT.TB, Latent M. tuberculosis infection, Rheumatoid arthritis

Article

Original

The Journal of the Korean Rheumatism Association 2006; 13(4): 285-290

Published online December 30, 2006

Copyright © Korean College of Rheumatology.

류마티스관절염 환자에서 잠복결핵 진단을 위한 투베르쿨린 검사와 T-SPOT.TB 사이의 일치율에 관한 연구

허지안·서수홍·박성환·조철수·김호연

가톨릭대학교 의과대학 내과학교실

Discrepancy between the Tuberculin Skin Test and the T-SPOT.TB for Detecting Latent Mycobacterium tuberculosis Infection in Patients with Rheumatoid Arthritis

Ji-An Hur, M.D., Soo-Hong Seo, M.D., Sung-Hwan Park, M.D., Chul-Soo Cho, M.D., Ho-Youn Kim, M.D.

Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
Objective: To evaluate c

Correspondence to:Sung-Hwan Park

Abstract

oncordance rate between tuberculin skin test (TST) and T-SPOT.TB (T-SPOT) for detecting latent tuberculosis in patients with rheumatoid arthritis (RA) received disease modifying antirheumatic drugs (DMARDs) and/or immunosuppressant. Methods: Fifty four patients with RA refractory to conventional DMARDs and planned ahead to be received tumor necrosis factor-α (TNF-α) blockade were enrolled in this study. The TST was performed by Mantoux method. Over 10 mm induration size was considered to be positive in the TST. The peripheral blood were collected from all patients and used for the T-SPOT. Results: Only six patients (11.11%) had a positive TST, and 48 patients (88.89%) had a negative TST. The mean TST values were 13.51⁑3.51 mm (range: 10∼19 mm) in TST (⁢) group and 2.50⁑3.12 mm (range: 0∼9 mm) in TST (⁣) group, respectively. T-SPOT was indeterminate in 7 patients (12.96%). Twenty-five patients (53.19%) had a positive result, and 22 patients (46.81%) had a negative result in 47 patients determinated with T-SPOT. There was poor overall agreement between results of TST and T-SPOT (p=0.194). Conclusion: There was no concordance between TST and T-SPOT in patients with RA received DMARDs and/or immunosuppressant. Therefore, the results of TST should be interpreted with caution, taking into consideration of the result of T-SPOT in patients with RA who are prone to having false negative of TST.

Keywords: Tuberculin skin test, T-SPOT.TB, Latent M. tuberculosis infection, Rheumatoid arthritis

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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