Original

The Journal of the Korean Rheumatism Association 2007; 14(3): 227-234

Published online September 30, 2007

© Korean College of Rheumatology

한국인 조기 류마티스관절염에서 항CCP항체의 진단적 의의

박성훈ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ김상경*ㆍ신임희**

대구가톨릭대학교 의과대학 내과학교실, 진단검사의학교실*, 의학통계학교실**

Diagnostic Significance of Anti-CCP Antibody in Korean Early Rheumatoid Arthritis

Sung-Hoon Park, Ji-Young Kim, Seong-Kyu Kim, Jung-Yoon Choe, Sang Kyung Kim*, Im-Hee Shin**

Departments of Internal Medicine, Laboratory Diagnostics*, and Medical Statistics**, School of Medicine, The Catholic University of Daegu, Daegu, Korea

Correspondence to : Jung-Yoon Choe

Abstract

Objective:To identify the sensitivity and specificity of the anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) in a diagnosis of Korean early rheumatoid arthritis (RA). Methods:Two hundred and sixty two patients diagnosed with RA were examined retrospectively and classified by three groups. A group 1 had a disease duration<24 months, and group 2 had a duration>24 months, and the third was a group of total patients. The sensitivity and specificity of the RF and anti-CCP in each group of RA were identified. Patients of the connective tissue disease other than rheumatoid arthritis were tested with RF and anti-CCP. Results: The sensitivity/specificity of RF and the anti-CCP in early RA were 90.4%/68.0% and 87.5%/89.3%, 91.3%/68.0%, 81.7%/89.3% in each, and 90.4%/68.0% and 84.7%/89.3% in the total RA patients. The accurate diagnosis rate, which is defined as (number of true positives plus true negatives)/ the total number of patients), of the RF and anti-CCP was 79.2%/88.4% in the early RA group, and 79.4% and 89.0% in the total patients group. Conclusion: Anti-CCP is more specific than RF in diagnosing RA. Although it is not statistically significant, diagnositc sensitivity of anti-CCP in early RA group is higher than that of established RA group.

Keywords Rheumatoid arthritis, Rheumatoid factor, Anti-cyclic citrullinated peptide

Article

Original

The Journal of the Korean Rheumatism Association 2007; 14(3): 227-234

Published online September 30, 2007

Copyright © Korean College of Rheumatology.

한국인 조기 류마티스관절염에서 항CCP항체의 진단적 의의

박성훈ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ김상경*ㆍ신임희**

대구가톨릭대학교 의과대학 내과학교실, 진단검사의학교실*, 의학통계학교실**

Diagnostic Significance of Anti-CCP Antibody in Korean Early Rheumatoid Arthritis

Sung-Hoon Park, Ji-Young Kim, Seong-Kyu Kim, Jung-Yoon Choe, Sang Kyung Kim*, Im-Hee Shin**

Departments of Internal Medicine, Laboratory Diagnostics*, and Medical Statistics**, School of Medicine, The Catholic University of Daegu, Daegu, Korea

Correspondence to:Jung-Yoon Choe

Abstract

Objective:To identify the sensitivity and specificity of the anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) in a diagnosis of Korean early rheumatoid arthritis (RA). Methods:Two hundred and sixty two patients diagnosed with RA were examined retrospectively and classified by three groups. A group 1 had a disease duration<24 months, and group 2 had a duration>24 months, and the third was a group of total patients. The sensitivity and specificity of the RF and anti-CCP in each group of RA were identified. Patients of the connective tissue disease other than rheumatoid arthritis were tested with RF and anti-CCP. Results: The sensitivity/specificity of RF and the anti-CCP in early RA were 90.4%/68.0% and 87.5%/89.3%, 91.3%/68.0%, 81.7%/89.3% in each, and 90.4%/68.0% and 84.7%/89.3% in the total RA patients. The accurate diagnosis rate, which is defined as (number of true positives plus true negatives)/ the total number of patients), of the RF and anti-CCP was 79.2%/88.4% in the early RA group, and 79.4% and 89.0% in the total patients group. Conclusion: Anti-CCP is more specific than RF in diagnosing RA. Although it is not statistically significant, diagnositc sensitivity of anti-CCP in early RA group is higher than that of established RA group.

Keywords: Rheumatoid arthritis, Rheumatoid factor, Anti-cyclic citrullinated peptide

JRD
Oct 01, 2024 Vol.31 No.4, pp. 191~263
COVER PICTURE
Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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