Case Report
The Journal of the Korean Rheumatism Association 2007; 14(4): 363-368
Published online December 30, 2007
© Korean College of Rheumatology
근염을 동반하지 않은 항합성효소증후군(Antisynthetase Syndrome)과 전신홍반루푸스의 중첩증후군 1예
고순영ㆍ서태호ㆍ이승민ㆍ장윤미ㆍ김해림ㆍ이상헌
건국대학교 의과대학 내과학교실 류마티스내과
Overlap Syndrome of Amyopathic Antisynthetase Syndrome and Systemic Lupus Erythematosus: A Case Report
Correspondence to : Sang-Heon Lee
Interstitial lung disease (ILD) with autoantibodies against antisynthetase may occur in the absence of clinically apparent myositis. We report 58-year-old woman who initially presented with dyspnea. The patient showed positive immunologic markers reflecting systemic lupus erythematosus, destructive polyarthritis, Raynaud's phenomenon, and ILD. There is no proximal muscle weakness in her symptoms. This syndrome was confirmed by positive antibodies to Jo-1. For the early diagnosis of this syndrome, the possibility of this syndrome including other connective tissue disease should be considered in patients presenting with symptoms related to ILD and positive anti-nuclear antibody.
Keywords Atnisynthetase syndrome, Anti-Jo-1 antibody, Interstitial lung diseases, Systemic lupus erythematosus
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Case Report
The Journal of the Korean Rheumatism Association 2007; 14(4): 363-368
Published online December 30, 2007
Copyright © Korean College of Rheumatology.
근염을 동반하지 않은 항합성효소증후군(Antisynthetase Syndrome)과 전신홍반루푸스의 중첩증후군 1예
고순영ㆍ서태호ㆍ이승민ㆍ장윤미ㆍ김해림ㆍ이상헌
건국대학교 의과대학 내과학교실 류마티스내과
Overlap Syndrome of Amyopathic Antisynthetase Syndrome and Systemic Lupus Erythematosus: A Case Report
Soon-Young Ko, M.D., Tae-Ho Seo, M.D., Seung-Min Lee, M.D., Yun-Mi Jang, M.D., Hae-Rim Kim, M.D., Sang-Heon Lee, M.D.
Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
Correspondence to:Sang-Heon Lee
Abstract
Interstitial lung disease (ILD) with autoantibodies against antisynthetase may occur in the absence of clinically apparent myositis. We report 58-year-old woman who initially presented with dyspnea. The patient showed positive immunologic markers reflecting systemic lupus erythematosus, destructive polyarthritis, Raynaud's phenomenon, and ILD. There is no proximal muscle weakness in her symptoms. This syndrome was confirmed by positive antibodies to Jo-1. For the early diagnosis of this syndrome, the possibility of this syndrome including other connective tissue disease should be considered in patients presenting with symptoms related to ILD and positive anti-nuclear antibody.
Keywords: Atnisynthetase syndrome, Anti-Jo-1 antibody, Interstitial lung diseases, Systemic lupus erythematosus
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