The Journal of the Korean Rheumatism Association 2007; 14(4): 390-394
Published online December 30, 2007
© Korean College of Rheumatology
김수경ㆍ정현영ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ박성훈
대구가톨릭대학교 의과대학 내과학교실
Correspondence to : Sung-Hoon Park
Systemic sclerosis is a connective tissue disease characterized by cutaneous and visceral fibrosis, as well as vascular disease involving arterioles, small and medium arteries of the peripheral circulation. Digital ulcers, defined as necrotic lesions that occur either at distal aspects of digits or over bony prominence, occur in up to 50% of patients with limited or diffuse systemic sclerosis. These lesions are exquisitely painful, heal slowly, and lead to substantial functional disability. We describe a 59-year-old woman with systemic sclerosis, suffering from a painful, non-healing digital ulcer despite conventional therapies, who demonstrated dramatic improvement with oral sildenafil treatment.
Keywords Systemic sclerosis, Digital ulcer, Sildenafil
The Journal of the Korean Rheumatism Association 2007; 14(4): 390-394
Published online December 30, 2007
Copyright © Korean College of Rheumatology.
김수경ㆍ정현영ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ박성훈
대구가톨릭대학교 의과대학 내과학교실
Soo-Kyung Kim, M.D., Hyun-Young Chung, M.D., Ji-Young Kim, M.D.,Seong-Kyu Kim, M.D., Jung-Yoon Choe, M.D., Sung-Hoon Park, M.D.
Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
Correspondence to:Sung-Hoon Park
Systemic sclerosis is a connective tissue disease characterized by cutaneous and visceral fibrosis, as well as vascular disease involving arterioles, small and medium arteries of the peripheral circulation. Digital ulcers, defined as necrotic lesions that occur either at distal aspects of digits or over bony prominence, occur in up to 50% of patients with limited or diffuse systemic sclerosis. These lesions are exquisitely painful, heal slowly, and lead to substantial functional disability. We describe a 59-year-old woman with systemic sclerosis, suffering from a painful, non-healing digital ulcer despite conventional therapies, who demonstrated dramatic improvement with oral sildenafil treatment.
Keywords: Systemic sclerosis, Digital ulcer, Sildenafil
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