Case Report

The Journal of the Korean Rheumatism Association 2007; 14(4): 390-394

Published online December 30, 2007

© Korean College of Rheumatology

전신성 경화증 환자에서 발생한 경구 Sildenafil (Phosphodiesterase-5 억제제) 투여로 호전된 수지궤양 1예

김수경ㆍ정현영ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ박성훈

대구가톨릭대학교 의과대학 내과학교실

A Case of Digital Ulcer in Systemic Sclerosis, Treated with Oral Sildenafil (Phosphodiesterase-5 Inhibitor, Viagra)

Soo-Kyung Kim, M.D., Hyun-Young Chung, M.D., Ji-Young Kim, M.D.,Seong-Kyu Kim, M.D., Jung-Yoon Choe, M.D., Sung-Hoon Park, M.D.

Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea

Correspondence to : Sung-Hoon Park

Abstract

Systemic sclerosis is a connective tissue disease characterized by cutaneous and visceral fibrosis, as well as vascular disease involving arterioles, small and medium arteries of the peripheral circulation. Digital ulcers, defined as necrotic lesions that occur either at distal aspects of digits or over bony prominence, occur in up to 50% of patients with limited or diffuse systemic sclerosis. These lesions are exquisitely painful, heal slowly, and lead to substantial functional disability. We describe a 59-year-old woman with systemic sclerosis, suffering from a painful, non-healing digital ulcer despite conventional therapies, who demonstrated dramatic improvement with oral sildenafil treatment.

Keywords Systemic sclerosis, Digital ulcer, Sildenafil

Article

Case Report

The Journal of the Korean Rheumatism Association 2007; 14(4): 390-394

Published online December 30, 2007

Copyright © Korean College of Rheumatology.

전신성 경화증 환자에서 발생한 경구 Sildenafil (Phosphodiesterase-5 억제제) 투여로 호전된 수지궤양 1예

김수경ㆍ정현영ㆍ김지영ㆍ김성규ㆍ최정윤ㆍ박성훈

대구가톨릭대학교 의과대학 내과학교실

A Case of Digital Ulcer in Systemic Sclerosis, Treated with Oral Sildenafil (Phosphodiesterase-5 Inhibitor, Viagra)

Soo-Kyung Kim, M.D., Hyun-Young Chung, M.D., Ji-Young Kim, M.D.,Seong-Kyu Kim, M.D., Jung-Yoon Choe, M.D., Sung-Hoon Park, M.D.

Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea

Correspondence to:Sung-Hoon Park

Abstract

Systemic sclerosis is a connective tissue disease characterized by cutaneous and visceral fibrosis, as well as vascular disease involving arterioles, small and medium arteries of the peripheral circulation. Digital ulcers, defined as necrotic lesions that occur either at distal aspects of digits or over bony prominence, occur in up to 50% of patients with limited or diffuse systemic sclerosis. These lesions are exquisitely painful, heal slowly, and lead to substantial functional disability. We describe a 59-year-old woman with systemic sclerosis, suffering from a painful, non-healing digital ulcer despite conventional therapies, who demonstrated dramatic improvement with oral sildenafil treatment.

Keywords: Systemic sclerosis, Digital ulcer, Sildenafil

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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