Systemic lupus erythematosus (SLE) and ulcerative colitis (UC) are both considered as systemic diseases with an abnormal immune response that depends on interactions between susceptibility genes and environmental factors. Patients with UC may share common manifestations with SLE, for example peripheral arthritis, oral ulcer. Although many autoimmune disorders tend to coexist in one patient, these two diseases are rarely associated with each other. We reported a case of a 36-year-old female where rectal bleeding was identified as ulcerative colitis. She was diagnosed as SLE prior to ulcerative colitis. There are no documented reports on SLE with ulcerative colitis in Korea.

Keywords: Systemic lupus erythematosus, Ulcerative colitis, Inflammatory bowel disease