Case Report
The Journal of the Korean Rheumatism Association 2009; 16(2): 156-160
Published online June 30, 2009
© Korean College of Rheumatology
강직척추염 환자에서 발생한 병적 골절을 동반한 다발성 골수종 1예
권혁용1ㆍ한승우1ㆍ권종규1ㆍ최진우1ㆍ이경숙1ㆍ권기태2ㆍ김건우1
대구파티마병원 류마티스내과1, 감염내과2
IgA Multiple Myeloma Presenting with Pathologic Fracture at Clavicle in a Patient with Ankylosing Spondylitis
Correspondence to : Seung Woo Han
Multiple myeloma (MM) is a malignant monoclonal proliferation of plasma cells that commonly causes pathologic fractures in the vertebrae, femur, humerus and rib. Although the association of MM and ankylosing spondylitis (AS) has rarely been reported, most of MM patients with AS share the characteristic of IgA type paraproteinemia, which suggests the presence of mechanisms that possibly connect the two conditions. In this report, we describe a 47-year-old man with a 25-year history of AS, and he was diagnosed as having IgA Պ type MM with a pathologic fracture at the left clavicle. To the best of our knowledge, this is the first case of IgA myeloma presenting with a pathologic fracture in a patient with AS. We report here on this case along conducting a review of the relevant medical literature.
Keywords Multiple myeloma, Ankylosing spondylitis
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Case Report
The Journal of the Korean Rheumatism Association 2009; 16(2): 156-160
Published online June 30, 2009
Copyright © Korean College of Rheumatology.
강직척추염 환자에서 발생한 병적 골절을 동반한 다발성 골수종 1예
권혁용1ㆍ한승우1ㆍ권종규1ㆍ최진우1ㆍ이경숙1ㆍ권기태2ㆍ김건우1
대구파티마병원 류마티스내과1, 감염내과2
IgA Multiple Myeloma Presenting with Pathologic Fracture at Clavicle in a Patient with Ankylosing Spondylitis
Hyuck Yong Kwon1, Seung Woo Han1, Jong Kyu Kwon1, Jin Woo Choi1, Kyung Sook Lee1, Ki Tae Kwon2, Gun Woo Kim1
Divisions of Rheumatology1 and Infectious Diseases2, Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea
Correspondence to:Seung Woo Han
Abstract
Multiple myeloma (MM) is a malignant monoclonal proliferation of plasma cells that commonly causes pathologic fractures in the vertebrae, femur, humerus and rib. Although the association of MM and ankylosing spondylitis (AS) has rarely been reported, most of MM patients with AS share the characteristic of IgA type paraproteinemia, which suggests the presence of mechanisms that possibly connect the two conditions. In this report, we describe a 47-year-old man with a 25-year history of AS, and he was diagnosed as having IgA Պ type MM with a pathologic fracture at the left clavicle. To the best of our knowledge, this is the first case of IgA myeloma presenting with a pathologic fracture in a patient with AS. We report here on this case along conducting a review of the relevant medical literature.
Keywords: Multiple myeloma, Ankylosing spondylitis
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