Case Report
The Journal of the Korean Rheumatism Association 2009; 16(4): 296-300
Published online December 30, 2009
© Korean College of Rheumatology
류마티스관절염 환자에서 Trimethoprim-Sulfamethoxazole 사용 중 발생한 혈전성 혈소판감소자반증(Thrombotic Thrombocytopenic Purpura) 1예
손지연ㆍ이경애ㆍ홍윤경ㆍ류완희
전북대학교 의학전문대학원 내과학교실 류마티스내과
Thrombotic Thrombocytopenic Purpura Induced by Trimethoprim-Sulfamethoxazole in a Patient with Rheumatoid Arthritis
Correspondence to : Wan-Hee Yoo
Thromobotic thrombocytopenic purpura (TTP) is a multisystem disorder that's characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia,and neurologic symptoms. TTP is associated with many diseases and several therapeutic drugs. We report here on the first Korean case of a patient with rheumatoid arthritis (RA) and who developed TTP that was associated with trimethoprim-sulfamethoxazole (TMP-SMX) in Korea. She recovered from the TTP following daily sessions of therapeutic plasma exchange (TPE) with fresh plasma replacement and glucocorticoid therapy. Awareness of the possible development of TTP in patient with RA and who is being treated with TMP-SMX is important for making the early diagnosis and administering proper treatment.
Keywords Thrombotic thrombocytopenic purpura, Rheumatoid arthritis, Trimethoprim- Sulfamethoxazole, Therapeutic plasma exchange, Glucocorticoid
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Case Report
The Journal of the Korean Rheumatism Association 2009; 16(4): 296-300
Published online December 30, 2009
Copyright © Korean College of Rheumatology.
류마티스관절염 환자에서 Trimethoprim-Sulfamethoxazole 사용 중 발생한 혈전성 혈소판감소자반증(Thrombotic Thrombocytopenic Purpura) 1예
손지연ㆍ이경애ㆍ홍윤경ㆍ류완희
전북대학교 의학전문대학원 내과학교실 류마티스내과
Thrombotic Thrombocytopenic Purpura Induced by Trimethoprim-Sulfamethoxazole in a Patient with Rheumatoid Arthritis
Ji Youn Sohn, Kyung Ae Lee, Yun Kyung Hong, Wan-Hee Yoo
Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and The Research Institute of Clinical Medicine, Jeonju, Korea
Correspondence to:Wan-Hee Yoo
Abstract
Thromobotic thrombocytopenic purpura (TTP) is a multisystem disorder that's characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia,and neurologic symptoms. TTP is associated with many diseases and several therapeutic drugs. We report here on the first Korean case of a patient with rheumatoid arthritis (RA) and who developed TTP that was associated with trimethoprim-sulfamethoxazole (TMP-SMX) in Korea. She recovered from the TTP following daily sessions of therapeutic plasma exchange (TPE) with fresh plasma replacement and glucocorticoid therapy. Awareness of the possible development of TTP in patient with RA and who is being treated with TMP-SMX is important for making the early diagnosis and administering proper treatment.
Keywords: Thrombotic thrombocytopenic purpura, Rheumatoid arthritis, Trimethoprim- Sulfamethoxazole, Therapeutic plasma exchange, Glucocorticoid
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