The Journal of the Korean Rheumatism Association 2009; 16(4): 338-343
Published online December 30, 2009
© Korean College of Rheumatology
윤보영ㆍ송화영ㆍ이주현ㆍ김경아
인제대학교 의과대학 내과학교실
Correspondence to : Bo Young Yoon
Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of the liver that is related to anti-mitochondria antibody and the disease is characterized by portal inflammation and immune-mediated destruction of the intrahepatic bile ducts. Several autoimmune diseases, such as hypothyroidism, Sjogren syndrome and systemic sclerosis (SSc), occur with increased frequency in patients with PBC. However, there are a few reports of a possible connection between systemic lupus erythematosus (SLE) or autoimmune hemolytic anemia (AIHA) and PBC. A 52-year-old female was admitted with fatigue and dyspnea that she had suffered with for the past month. She had suffered from jaundice for 2 weeks before admission. Many of the clinical manifestations and laboratory findings suggested the diagnosis of PBC with SSc of the limited type and AIHA. She was treated with methylprednisolone pulse therapy and ursodeoxycholic acid. We consequently diagnosed her as having SLE, as she satisfied the 4 relative diagnostic criteria-arthritis, AIHA, positive antinuclear antibody and positive antiphospholipid antibodies.
Keywords Primary biliary cirrhosis, Systemic sclerosis, Autoimmune hemolytic anemia, Systemic lupus erythematosus
The Journal of the Korean Rheumatism Association 2009; 16(4): 338-343
Published online December 30, 2009
Copyright © Korean College of Rheumatology.
윤보영ㆍ송화영ㆍ이주현ㆍ김경아
인제대학교 의과대학 내과학교실
Bo Young Yoon, Hwa Young Song, Ju Hyun Lee, Kyung Ah Kim
Department of Internal Medicine, Inje University College of Medicine, Goyang, Korea
Correspondence to:Bo Young Yoon
Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of the liver that is related to anti-mitochondria antibody and the disease is characterized by portal inflammation and immune-mediated destruction of the intrahepatic bile ducts. Several autoimmune diseases, such as hypothyroidism, Sjogren syndrome and systemic sclerosis (SSc), occur with increased frequency in patients with PBC. However, there are a few reports of a possible connection between systemic lupus erythematosus (SLE) or autoimmune hemolytic anemia (AIHA) and PBC. A 52-year-old female was admitted with fatigue and dyspnea that she had suffered with for the past month. She had suffered from jaundice for 2 weeks before admission. Many of the clinical manifestations and laboratory findings suggested the diagnosis of PBC with SSc of the limited type and AIHA. She was treated with methylprednisolone pulse therapy and ursodeoxycholic acid. We consequently diagnosed her as having SLE, as she satisfied the 4 relative diagnostic criteria-arthritis, AIHA, positive antinuclear antibody and positive antiphospholipid antibodies.
Keywords: Primary biliary cirrhosis, Systemic sclerosis, Autoimmune hemolytic anemia, Systemic lupus erythematosus
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