Case Report
The Journal of the Korean Rheumatism Association 2010; 17(2): 177-182
Published online June 30, 2010
© Korean College of Rheumatology
루푸스신염에 동반된 가역적 후두부 뇌병증 증후군
김현경ㆍ김현아ㆍ장은정ㆍ서창희
아주대학교 의과대학 아주대학교병원 알레르기-류마티스내과학교실
Posterior Reversible Encephalopathy Syndrome in a Patient with Lupus Nephritis
Correspondence to : Chang Hee Suh
Posterior reversible encephalopathy syndrome (PRES) has been described in various clinical settings, including severe hypertension, eclampsia, lupus and immunosuppressive therapy. We report a 27 year-old female systemic lupus erythematosus patient who developed severe headache, seizure and hemiparesis during her lupus nephritis flare. Magnetic resonance image (MRI) showed multi-focal high signal intensity lesions in the parieto-occipital cortex bilaterally and in the subcortical white matter. Her condition improved with immunosuppressive treatments, antihypertensives and hemodialysis. The extent of her lesions decreased on follow-up MRI 2 months later. This case suggests that PRES can be treated with immunosuppressive drugs that do not increase blood pressure.
Keywords Systemic lupus erythematosus, Posterior reversible encephalopathy syndrome, Lupus nephritis
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Case Report
The Journal of the Korean Rheumatism Association 2010; 17(2): 177-182
Published online June 30, 2010
Copyright © Korean College of Rheumatology.
루푸스신염에 동반된 가역적 후두부 뇌병증 증후군
김현경ㆍ김현아ㆍ장은정ㆍ서창희
아주대학교 의과대학 아주대학교병원 알레르기-류마티스내과학교실
Posterior Reversible Encephalopathy Syndrome in a Patient with Lupus Nephritis
Hyun Kyung Kim, Hyoun Ah Kim, Eun Jung Jang, Chang Hee Suh
Department of Allergy and Rheumatology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea
Correspondence to:Chang Hee Suh
Abstract
Posterior reversible encephalopathy syndrome (PRES) has been described in various clinical settings, including severe hypertension, eclampsia, lupus and immunosuppressive therapy. We report a 27 year-old female systemic lupus erythematosus patient who developed severe headache, seizure and hemiparesis during her lupus nephritis flare. Magnetic resonance image (MRI) showed multi-focal high signal intensity lesions in the parieto-occipital cortex bilaterally and in the subcortical white matter. Her condition improved with immunosuppressive treatments, antihypertensives and hemodialysis. The extent of her lesions decreased on follow-up MRI 2 months later. This case suggests that PRES can be treated with immunosuppressive drugs that do not increase blood pressure.
Keywords: Systemic lupus erythematosus, Posterior reversible encephalopathy syndrome, Lupus nephritis
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