The Journal of the Korean Rheumatism Association 2010; 17(3): 295-300
Published online September 30, 2010
© Korean College of Rheumatology
정 경 희1ㆍ최 정 혜2ㆍ이 혜 순1
한양대학교 의과대학 내과학교실 류마티스내과1, 혈액종양내과2
Correspondence to : Hye-Soon Lee
Acquired hemophilia is a rare disease caused by an autoimmune reaction to coagulation factor VIII, The mortality rate of this disease is very high (8∼22%). Clinical manifestations are different from congenital hemophilia. Various diseases are associated with acquired hemophilia, including autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis (RA), tumors, inflammatory bowel disease, psoriasis, asthma, diabetes, acute hepatitis B or C, and drug reactions. However, the underlying cause is unknown in approximately 50% of cases. A few cases of acquired hemophilia with RA have been published. However, no cases have been reported in Korea. We had a patient with longstanding RA and acquired hemophilia who was suffering from upper and lower extremity purpura with a deep intramuscular hematoma. The patient was successfully treated using cyclophosphamide combined with steroid.
Keywords Rheumatoid arthritis, Acquired hemophilia
The Journal of the Korean Rheumatism Association 2010; 17(3): 295-300
Published online September 30, 2010
Copyright © Korean College of Rheumatology.
정 경 희1ㆍ최 정 혜2ㆍ이 혜 순1
한양대학교 의과대학 내과학교실 류마티스내과1, 혈액종양내과2
Kyong-Hee Jung1, Jung-Hye Choi2, Hye-Soon Lee1
Division of Rheumatology1, Division of Hemato-oncology2, Department of Internal Medicine, Guri Hospital, Hanyang University College of Medicine, Guri, Korea
Correspondence to:Hye-Soon Lee
Acquired hemophilia is a rare disease caused by an autoimmune reaction to coagulation factor VIII, The mortality rate of this disease is very high (8∼22%). Clinical manifestations are different from congenital hemophilia. Various diseases are associated with acquired hemophilia, including autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis (RA), tumors, inflammatory bowel disease, psoriasis, asthma, diabetes, acute hepatitis B or C, and drug reactions. However, the underlying cause is unknown in approximately 50% of cases. A few cases of acquired hemophilia with RA have been published. However, no cases have been reported in Korea. We had a patient with longstanding RA and acquired hemophilia who was suffering from upper and lower extremity purpura with a deep intramuscular hematoma. The patient was successfully treated using cyclophosphamide combined with steroid.
Keywords: Rheumatoid arthritis, Acquired hemophilia
Byeongzu Ghang, M.D., Ph.D., Jin Kyun Park, M.D., Ph.D., Ji Hyeon Ju, M.D., Ph.D., Seungwoo Han, M.D., Ph.D.
J Rheum Dis -0001; ():Shohei Anno, M.D., Kentaro Inui, M.D., Ph.D., Masahiro Tada, M.D., Ph.D., Yuko Sugioka, M.D., Ph.D., Tadashi Okano, M.D., Ph.D.,, Kenji Mamoto, M.D., Ph.D., Tatsuya Koike, M.D., Ph.D.
J Rheum Dis -0001; ():Soo Min Ahn, M.D., Ph.D., Seonok Kim, MSc., Ye-Jee Kim, Ph.D., Seokchan Hong, M.D., Ph.D., Chang-Keun Lee, M.D., Ph.D., Bin Yoo, M.D., Ph.D., Ji Seon Oh, M.D., Ph.D., Yong-Gil Kim, M.D., Ph.D.
J Rheum Dis -0001; ():