Case Report

The Journal of the Korean Rheumatism Association 2010; 17(3): 295-300

Published online September 30, 2010

© Korean College of Rheumatology

류마티스관절염 환자에서 발생한 후천성 혈우병 1예

정 경 희1ㆍ최 정 혜2ㆍ이 혜 순1

한양대학교 의과대학 내과학교실 류마티스내과1, 혈액종양내과2

Acquired Hemophilia in a Patient with Rheumatoid Arthritis

Kyong-Hee Jung1, Jung-Hye Choi2, Hye-Soon Lee1

Division of Rheumatology1, Division of Hemato-oncology2, Department of Internal Medicine, Guri Hospital, Hanyang University College of Medicine, Guri, Korea

Correspondence to : Hye-Soon Lee

Abstract

Acquired hemophilia is a rare disease caused by an autoimmune reaction to coagulation factor VIII, The mortality rate of this disease is very high (8∼22%). Clinical manifestations are different from congenital hemophilia. Various diseases are associated with acquired hemophilia, including autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis (RA), tumors, inflammatory bowel disease, psoriasis, asthma, diabetes, acute hepatitis B or C, and drug reactions. However, the underlying cause is unknown in approximately 50% of cases. A few cases of acquired hemophilia with RA have been published. However, no cases have been reported in Korea. We had a patient with longstanding RA and acquired hemophilia who was suffering from upper and lower extremity purpura with a deep intramuscular hematoma. The patient was successfully treated using cyclophosphamide combined with steroid.

Keywords Rheumatoid arthritis, Acquired hemophilia

Article

Case Report

The Journal of the Korean Rheumatism Association 2010; 17(3): 295-300

Published online September 30, 2010

Copyright © Korean College of Rheumatology.

류마티스관절염 환자에서 발생한 후천성 혈우병 1예

정 경 희1ㆍ최 정 혜2ㆍ이 혜 순1

한양대학교 의과대학 내과학교실 류마티스내과1, 혈액종양내과2

Acquired Hemophilia in a Patient with Rheumatoid Arthritis

Kyong-Hee Jung1, Jung-Hye Choi2, Hye-Soon Lee1

Division of Rheumatology1, Division of Hemato-oncology2, Department of Internal Medicine, Guri Hospital, Hanyang University College of Medicine, Guri, Korea

Correspondence to:Hye-Soon Lee

Abstract

Acquired hemophilia is a rare disease caused by an autoimmune reaction to coagulation factor VIII, The mortality rate of this disease is very high (8∼22%). Clinical manifestations are different from congenital hemophilia. Various diseases are associated with acquired hemophilia, including autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis (RA), tumors, inflammatory bowel disease, psoriasis, asthma, diabetes, acute hepatitis B or C, and drug reactions. However, the underlying cause is unknown in approximately 50% of cases. A few cases of acquired hemophilia with RA have been published. However, no cases have been reported in Korea. We had a patient with longstanding RA and acquired hemophilia who was suffering from upper and lower extremity purpura with a deep intramuscular hematoma. The patient was successfully treated using cyclophosphamide combined with steroid.

Keywords: Rheumatoid arthritis, Acquired hemophilia

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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