Case Report

The Journal of the Korean Rheumatism Association 2010; 17(4): 400-405

Published online December 30, 2010

© Korean College of Rheumatology

전신성 경화증에 동반된 사르코이드증 1예

김동찬1ㆍ임동휘1ㆍ김영택1ㆍ고주연2ㆍ박찬금3ㆍ박성수1ㆍ전재범4

한양대학교 의과대학 내과학교실1, 피부과학교실2, 병리학교실3, 한양대학교 류마티스병원 류마티스내과4

Systemic Sclerosis Coincidence with Sarcoidosis: A Case Report and Review of the Literature

Dong Chan Kim1, Dong Hwi Rim1, Young Taek Kim1, Joo Yeon Ko2, Chan Kum Park3, Sung Soo Park1, Jae-Bum Jun4

Departments of Internal Medicine1, Dermatology2 and Pathology3, Hanyang University College of Medicine, Department of Rheumatology, Hanyang University Hospital for Rheumatic Disease4, Seoul, Korea

Correspondence to : Jae-Bum Jun

Abstract

A 62-year-old Korean woman was admitted to our department to evaluate a chronic cough and sputum, which had begun several weeks ago. The patient had been diagnosed with systemic sclerosis in 2004. Autoantibody screening tests were negative for the anticentromere and antitopoisomerase antibodies. She received therapy with combined cyclophosphamide, a calcium channel blocker, D-penicillamine, and low dose steroid. In 2006, a pulmonary function test (PFT) showed a restrictive pattern, and a computed tomography (CT) scan of the lungs revealed interstitial lung disease, but no symptoms were present, so we maintained her on the medication. In October 2008, a chest x-ray and CT scan of the lungs demonstrated aggravation with bilateral basal interstitial infiltrates and hilar lymphadenopathy. Cyclophosphamide pulse therapy was conducted six times during 6 months, but there was no change on her chest CT and PFT, and she had no symptoms, so we decided to follow up. On admission, no significant interval change in the reticular opacity of both lower lungs was observed, but several lymph nodes were enlarged on a chest and neck CT. The skin showed multiple large polygonal-shaped scaled lesions on her upper and lower extremities. Biopsies were taken from the skin of the lower extremities and the left cervical lymph node. Typical non-caseating granulomas corresponding to sarcoidosis were found along with systemic sclerosis findings.

Keywords Systemic sclerosis, Sarcoidosis

Article

Case Report

The Journal of the Korean Rheumatism Association 2010; 17(4): 400-405

Published online December 30, 2010

Copyright © Korean College of Rheumatology.

전신성 경화증에 동반된 사르코이드증 1예

김동찬1ㆍ임동휘1ㆍ김영택1ㆍ고주연2ㆍ박찬금3ㆍ박성수1ㆍ전재범4

한양대학교 의과대학 내과학교실1, 피부과학교실2, 병리학교실3, 한양대학교 류마티스병원 류마티스내과4

Systemic Sclerosis Coincidence with Sarcoidosis: A Case Report and Review of the Literature

Dong Chan Kim1, Dong Hwi Rim1, Young Taek Kim1, Joo Yeon Ko2, Chan Kum Park3, Sung Soo Park1, Jae-Bum Jun4

Departments of Internal Medicine1, Dermatology2 and Pathology3, Hanyang University College of Medicine, Department of Rheumatology, Hanyang University Hospital for Rheumatic Disease4, Seoul, Korea

Correspondence to:Jae-Bum Jun

Abstract

A 62-year-old Korean woman was admitted to our department to evaluate a chronic cough and sputum, which had begun several weeks ago. The patient had been diagnosed with systemic sclerosis in 2004. Autoantibody screening tests were negative for the anticentromere and antitopoisomerase antibodies. She received therapy with combined cyclophosphamide, a calcium channel blocker, D-penicillamine, and low dose steroid. In 2006, a pulmonary function test (PFT) showed a restrictive pattern, and a computed tomography (CT) scan of the lungs revealed interstitial lung disease, but no symptoms were present, so we maintained her on the medication. In October 2008, a chest x-ray and CT scan of the lungs demonstrated aggravation with bilateral basal interstitial infiltrates and hilar lymphadenopathy. Cyclophosphamide pulse therapy was conducted six times during 6 months, but there was no change on her chest CT and PFT, and she had no symptoms, so we decided to follow up. On admission, no significant interval change in the reticular opacity of both lower lungs was observed, but several lymph nodes were enlarged on a chest and neck CT. The skin showed multiple large polygonal-shaped scaled lesions on her upper and lower extremities. Biopsies were taken from the skin of the lower extremities and the left cervical lymph node. Typical non-caseating granulomas corresponding to sarcoidosis were found along with systemic sclerosis findings.

Keywords: Systemic sclerosis, Sarcoidosis

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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