Case Report
The Journal of the Korean Rheumatism Association 2010; 17(4): 431-436
Published online December 30, 2010
© Korean College of Rheumatology
전신홍반루푸스와 병발한 비분비형 다발성 골수종 1예
정유진1ㆍ김현숙1ㆍ김은정1ㆍ김윤성1ㆍ박치영1ㆍ신봉석2ㆍ박 건3
조선대학교 의과대학 내과학교실1, 피부과학교실2, 진단검사의학교실3
A Case of Non Secretory Type Multiple Myeloma Associated with Systemic Lupus Erythematosus
Correspondence to : Hyun-Sook Kim
The development of malignant tumors is a more frequent finding in lupus patients than the general population. However, the incidence of multiple myeloma associated with systemic lupus erythematosus (SLE) is a rare manifestation. SLE is an autoimmune disease characterized by B cell hyperactivity, formation of autoantibodies, and multi-clonal hypergammaglobulinemia. Serum immunoglobulin increases, with a specific increase in IgG, which is due to an increase in autoantibody formation related to extrinsic and intrinsic antigens. We report on a patient with SLE combined with IgG, lambda type nonsecretory multiple myeloma, which was diagnosed with refractory anemia and hypergammaglobulinemia.
Keywords Nonsecretory multiple myeloma, Systemic lupus erythematosus
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Case Report
The Journal of the Korean Rheumatism Association 2010; 17(4): 431-436
Published online December 30, 2010
Copyright © Korean College of Rheumatology.
전신홍반루푸스와 병발한 비분비형 다발성 골수종 1예
정유진1ㆍ김현숙1ㆍ김은정1ㆍ김윤성1ㆍ박치영1ㆍ신봉석2ㆍ박 건3
조선대학교 의과대학 내과학교실1, 피부과학교실2, 진단검사의학교실3
A Case of Non Secretory Type Multiple Myeloma Associated with Systemic Lupus Erythematosus
Yu-Jin Jeong1, Hyun-Sook Kim1, Eun-Jeong Kim1, Yun Sung Kim1, Chi-Young Park1, Bong-Seok Shin2, Geon Park3
Departments of Internal Medicine1, Dermatology2, Laboratory Medicine3, Chosun University College of Medicine, Gwangju, Korea
Correspondence to:Hyun-Sook Kim
Abstract
The development of malignant tumors is a more frequent finding in lupus patients than the general population. However, the incidence of multiple myeloma associated with systemic lupus erythematosus (SLE) is a rare manifestation. SLE is an autoimmune disease characterized by B cell hyperactivity, formation of autoantibodies, and multi-clonal hypergammaglobulinemia. Serum immunoglobulin increases, with a specific increase in IgG, which is due to an increase in autoantibody formation related to extrinsic and intrinsic antigens. We report on a patient with SLE combined with IgG, lambda type nonsecretory multiple myeloma, which was diagnosed with refractory anemia and hypergammaglobulinemia.
Keywords: Nonsecretory multiple myeloma, Systemic lupus erythematosus
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