J Rheum Dis 2011; 18(1): 11-18
Published online March 30, 2011
© Korean College of Rheumatology
지종대1ㆍ김태환2ㆍ이빛나라2ㆍ최성재1ㆍ이영호1ㆍ송관규1
고려대학교 의과대학 류마티스내과학교실1, 한양대학교 의과대학 류마티스병원2
Correspondence to : Jong Dae Ji
Objective. To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB) CD14+ osteoclast precursors. Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis, the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR. Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis- related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors. Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors.
Keywords Rheumatoid arthritis, Synovial osteoclast precursors, Osteoclastogenesis
J Rheum Dis 2011; 18(1): 11-18
Published online March 30, 2011
Copyright © Korean College of Rheumatology.
지종대1ㆍ김태환2ㆍ이빛나라2ㆍ최성재1ㆍ이영호1ㆍ송관규1
고려대학교 의과대학 류마티스내과학교실1, 한양대학교 의과대학 류마티스병원2
Jong Dae Ji1, Tae-Hwan Kim2, Bitnara Lee2, Sung Jae Choi1, Young Ho Lee1, Gwan Gyu Song1
Department of Rheumatology, College of Medicine, Korea University1, The Hospital for Rheumatic Diseases, College of Medicine, Hanyang University2, Seoul, Korea
Correspondence to:Jong Dae Ji
Objective. To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB) CD14+ osteoclast precursors. Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis, the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR. Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis- related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors. Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors.
Keywords: Rheumatoid arthritis, Synovial osteoclast precursors, Osteoclastogenesis
Won-Ju Jeong, Ha-Jeong Kim
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