Case Report

J Rheum Dis 2011; 18(1): 36-40

Published online March 30, 2011

© Korean College of Rheumatology

급성 다발성 관절염으로 발병한 카플란 증후군 1예

류한희ㆍ장성혜ㆍ김혜원ㆍ신기철ㆍ이은봉ㆍ임재준ㆍ송영욱

서울대학교 의과대학 서울대학교병원 내과학교실

A Case of Caplan's Syndrome Presenting as Acute Onset Polyarthritis

Han Hee Ryu, Sung Hae Chang, Hye Won Kim, Kichul Shin, Eun Bong Lee, Jae Joon Yim, Yeong Wook Song

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

Correspondence to : Yeong Wook Song

Abstract

Caplan originally described distinctive pulmonary nodules in miners who had suffered from rheumatoid arthritis. Later, the pulmonary nodules, together with a history of rheumatoid arthritis and exposure to inorganic dust were called Caplan's syndrome. This syndrome has been described by case reports in many countries but only two cases have been reported in Korea up to now. The patient in this case report was a 70-years-old man who had worked in the construction field for 20 years mainly demolishing buildings. He was diagnosed with silicosis by a lung biopsy 1 year prior to admission. He suddenly developed arthralgia and morning stiffness in multiple joints 2 weeks prior to admission. Chest imaging revealed aggravation of the bilateral pulmonary nodules. He was diagnosed with seropositive rheumatoid arthritis. The lung nodules, arthralgia, and morning stiffness improved clinically after treatment with the corticosteroid and disease modifying anti-rheumatic drugs.

Keywords Caplan's syndrome, Rheumatoid arthritis, Pneumoconiosis, Silicosis

Article

Case Report

J Rheum Dis 2011; 18(1): 36-40

Published online March 30, 2011

Copyright © Korean College of Rheumatology.

급성 다발성 관절염으로 발병한 카플란 증후군 1예

류한희ㆍ장성혜ㆍ김혜원ㆍ신기철ㆍ이은봉ㆍ임재준ㆍ송영욱

서울대학교 의과대학 서울대학교병원 내과학교실

A Case of Caplan's Syndrome Presenting as Acute Onset Polyarthritis

Han Hee Ryu, Sung Hae Chang, Hye Won Kim, Kichul Shin, Eun Bong Lee, Jae Joon Yim, Yeong Wook Song

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

Correspondence to:Yeong Wook Song

Abstract

Caplan originally described distinctive pulmonary nodules in miners who had suffered from rheumatoid arthritis. Later, the pulmonary nodules, together with a history of rheumatoid arthritis and exposure to inorganic dust were called Caplan's syndrome. This syndrome has been described by case reports in many countries but only two cases have been reported in Korea up to now. The patient in this case report was a 70-years-old man who had worked in the construction field for 20 years mainly demolishing buildings. He was diagnosed with silicosis by a lung biopsy 1 year prior to admission. He suddenly developed arthralgia and morning stiffness in multiple joints 2 weeks prior to admission. Chest imaging revealed aggravation of the bilateral pulmonary nodules. He was diagnosed with seropositive rheumatoid arthritis. The lung nodules, arthralgia, and morning stiffness improved clinically after treatment with the corticosteroid and disease modifying anti-rheumatic drugs.

Keywords: Caplan's syndrome, Rheumatoid arthritis, Pneumoconiosis, Silicosis

JRD
Oct 01, 2024 Vol.31 No.4, pp. 191~263
COVER PICTURE
Ancestry-driven pathways for SLE-risk SNP-associated genes. The ancestry-driven key signaling pathways in Asians, Europeans, and African Americans were analyzed by enrichr (https://maayanlab.cloud/Enrichr/#libraries) using non-HLA SNP-associated genes. SLE: systemic lupus erythematosus, SNP: single-nucleotide polymorphism, JAK–STAT: janus kinase–signal transducers and activators of transcription, IFN: interferon gamma. (J Rheum Dis 2024;31:200-211)

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