Case Report

J Rheum Dis 2011; 18(1): 50-54

Published online March 30, 2011

© Korean College of Rheumatology

레이노 현상에 의한 수지 괴사로 진단된 원발쓸개관간경화 1예

황윤우ㆍ윤 환ㆍ강종식ㆍ이상아ㆍ이우제ㆍ이기업ㆍ박중열

울산대학교 의과대학 서울아산병원 내과학교실

The Primary Biliary Cirrhosis Presenting with Raynaud's Disease and Digital Necrosis

Jenie Yoonoo Hwang, Hwang Yoon, Jong Sik Kang, Sang Ah Lee, Woo Je Lee, Ki-Up Lee, Joong Yeol Park

Department of Internal Medicine, University of Ulsan College of Medicine, Seoul Asan Medical Center, Seoul, Korea

Correspondence to : Joong Yeol Park

Abstract

Necrosis of the upper extremity occurs rarely in type 2 diabetic patients compared to lower extremity necrosis. We report a 69-year-old woman with type 2 diabetes mellitus who presented with necrosis of the left 5th finger tip. The patient had primary biliary cirrhosis accompanied by necrosis of the fingertip due to severe Raynaud's phenomenon. Primary biliary cirrhosis (PBC) is a typical autoimmune disease, which can in rare cases be accompanied by autoimmune symptoms including sicca symptom and Raynaud's phenomenon. Furthermore, autoimmune diseases, such as systemic sclerosis, rheumatoid arthritis and undifferentiated connective tissue disease (UCTD) can be associated. Although every type of vascular etiology should be considered as a cause of digital necrosis, Raynaud's phenomenon is usually not considered in diabetes. We report this case of finger tip necrosis due to severe Raynaud's phenomenon accompanied by PBC and UCTD in a diabetic patient.

Keywords Primary biliary cirrhosis, Undifferentiated connective tissue disease, Raynaud's phenomenon, Necrosis, Fingers, Diabetes mellitus

Article

Case Report

J Rheum Dis 2011; 18(1): 50-54

Published online March 30, 2011

Copyright © Korean College of Rheumatology.

레이노 현상에 의한 수지 괴사로 진단된 원발쓸개관간경화 1예

황윤우ㆍ윤 환ㆍ강종식ㆍ이상아ㆍ이우제ㆍ이기업ㆍ박중열

울산대학교 의과대학 서울아산병원 내과학교실

The Primary Biliary Cirrhosis Presenting with Raynaud's Disease and Digital Necrosis

Jenie Yoonoo Hwang, Hwang Yoon, Jong Sik Kang, Sang Ah Lee, Woo Je Lee, Ki-Up Lee, Joong Yeol Park

Department of Internal Medicine, University of Ulsan College of Medicine, Seoul Asan Medical Center, Seoul, Korea

Correspondence to:Joong Yeol Park

Abstract

Necrosis of the upper extremity occurs rarely in type 2 diabetic patients compared to lower extremity necrosis. We report a 69-year-old woman with type 2 diabetes mellitus who presented with necrosis of the left 5th finger tip. The patient had primary biliary cirrhosis accompanied by necrosis of the fingertip due to severe Raynaud's phenomenon. Primary biliary cirrhosis (PBC) is a typical autoimmune disease, which can in rare cases be accompanied by autoimmune symptoms including sicca symptom and Raynaud's phenomenon. Furthermore, autoimmune diseases, such as systemic sclerosis, rheumatoid arthritis and undifferentiated connective tissue disease (UCTD) can be associated. Although every type of vascular etiology should be considered as a cause of digital necrosis, Raynaud's phenomenon is usually not considered in diabetes. We report this case of finger tip necrosis due to severe Raynaud's phenomenon accompanied by PBC and UCTD in a diabetic patient.

Keywords: Primary biliary cirrhosis, Undifferentiated connective tissue disease, Raynaud's phenomenon, Necrosis, Fingers, Diabetes mellitus

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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