Case Report
J Rheum Dis 2011; 18(1): 60-63
Published online March 30, 2011
© Korean College of Rheumatology
류마티스관절염에 동반된 클라인펠터 증후군 1예
모상일ㆍ이혁규ㆍ조아라ㆍ정혜경ㆍ김기원ㆍ이한민ㆍ강병일ㆍ고규봉ㆍ이세환ㆍ나성수
순천향대학교 의과대학 내과학교실
A Case of Klinefelter's Syndrome Associated with Rheumatoid Arthritis
Correspondence to : Seong-Su Nah
Klinefelter's syndrome (KFS) is a gonosomal aberration disease that occurs in males, and is characterized by 47, XXY karyotype, hypogonadism and a lack of secondary sexual characteristics. A potential link between this hormonally deficient syndrome and autoimmune disease, particularly systemic lupus erythematosus (SLE), has been reported. On the other hand, KFS is rarely reported to be accompanied by rheumatoid arthritis (RA), and there are no Korean cases reported. We report the first Korean case of a KFS patient with sero-positive RA and discuss the role of the pathogenesis of RA with KFS.
Keywords Klinefelter's syndrome, Rheumatoid arthritis, X chromosome
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Case Report
J Rheum Dis 2011; 18(1): 60-63
Published online March 30, 2011
Copyright © Korean College of Rheumatology.
류마티스관절염에 동반된 클라인펠터 증후군 1예
모상일ㆍ이혁규ㆍ조아라ㆍ정혜경ㆍ김기원ㆍ이한민ㆍ강병일ㆍ고규봉ㆍ이세환ㆍ나성수
순천향대학교 의과대학 내과학교실
A Case of Klinefelter's Syndrome Associated with Rheumatoid Arthritis
Sang Il Mo, Hyeok Gyu Lee, A Ra Cho, Hye Kyoung Chung, Ki Won Kim, Han Min Lee, Byong Il Kang, Gyu Bong Ko, Se-Whan Lee, Seong-Su Nah
Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea
Correspondence to:Seong-Su Nah
Abstract
Klinefelter's syndrome (KFS) is a gonosomal aberration disease that occurs in males, and is characterized by 47, XXY karyotype, hypogonadism and a lack of secondary sexual characteristics. A potential link between this hormonally deficient syndrome and autoimmune disease, particularly systemic lupus erythematosus (SLE), has been reported. On the other hand, KFS is rarely reported to be accompanied by rheumatoid arthritis (RA), and there are no Korean cases reported. We report the first Korean case of a KFS patient with sero-positive RA and discuss the role of the pathogenesis of RA with KFS.
Keywords: Klinefelter's syndrome, Rheumatoid arthritis, X chromosome
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