J Rheum Dis 2011; 18(4): 315-319
Published online December 30, 2011
© Korean College of Rheumatology
박희진1ㆍ박윤혜1ㆍ박경혜1ㆍ김미현1ㆍ최은영1ㆍ한정우1ㆍ홍지영1ㆍ장명희2ㆍ김선정3ㆍ심주은4ㆍ기정혜5ㆍ이상원1ㆍ박용범1ㆍ이수곤1ㆍ이찬희2
연세대학교 의과대학 내과학교실1, 국민건강보험공단 일산병원 내과2, 핵의학과3, 영상의학과4, 병리과5
Correspondence to : Chan Hee Lee
Several autoimmune and chronic inflammatory conditions have been consistently linked with an increased risk of hematologic malignancies. Although ankylosing spondylitis (AS) is a chronic inflammatory disease, previous studies have demonstrated that it is not associated with an increase in risk of malignant lymphomas. Cases of AS accompanied by hematologic malignancies such as multiple myeloma, chronic myelogenous leukemia, and Hodgkin's disease have been reported. In Korea, AS with non- Hodgkin's lymphoma or follicular lymphoma has not been reported. We experienced a 38-year-old male who had been diagnosed with follicular lymphoma with bone metastasis, who achieved complete remission after having been treated with chemotherapy, developed new inflammatory back pain. An MRI of his hip showed an active inflammation of the left sacroiliac joint and a positive HLA-B27. The patient was diagnosed with AS and was treated with naproxen, which improved the pain in his back and buttock.
Keywords Ankylosing spondylitis, Non-Hodgkin's lymphoma, Follicular lymphoma, Inflammatory back pain
J Rheum Dis 2011; 18(4): 315-319
Published online December 30, 2011
Copyright © Korean College of Rheumatology.
박희진1ㆍ박윤혜1ㆍ박경혜1ㆍ김미현1ㆍ최은영1ㆍ한정우1ㆍ홍지영1ㆍ장명희2ㆍ김선정3ㆍ심주은4ㆍ기정혜5ㆍ이상원1ㆍ박용범1ㆍ이수곤1ㆍ이찬희2
연세대학교 의과대학 내과학교실1, 국민건강보험공단 일산병원 내과2, 핵의학과3, 영상의학과4, 병리과5
Hee Jin Park1, Yoon Hea Park1, Kyeong Hye Park1, Mihyun Kim1, Eun Yeong Choe1, Jung Woo Han1, Ji Young Hong1, Myung Hee Chang2, Sun Jung Kim3, Joo Eun Shim4, Jeong Hae Kie5, Sang-Won Lee1, Yong-Beom Park1, Soo-Kon Lee1, Chan Hee Lee2
Department of Internal Medicine, Yonsei University College of Medicine1, Seoul, Departments of Internal Medicine2, Nuclear Medicine3, Radiology4, and Pathology5, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea
Correspondence to:Chan Hee Lee
Several autoimmune and chronic inflammatory conditions have been consistently linked with an increased risk of hematologic malignancies. Although ankylosing spondylitis (AS) is a chronic inflammatory disease, previous studies have demonstrated that it is not associated with an increase in risk of malignant lymphomas. Cases of AS accompanied by hematologic malignancies such as multiple myeloma, chronic myelogenous leukemia, and Hodgkin's disease have been reported. In Korea, AS with non- Hodgkin's lymphoma or follicular lymphoma has not been reported. We experienced a 38-year-old male who had been diagnosed with follicular lymphoma with bone metastasis, who achieved complete remission after having been treated with chemotherapy, developed new inflammatory back pain. An MRI of his hip showed an active inflammation of the left sacroiliac joint and a positive HLA-B27. The patient was diagnosed with AS and was treated with naproxen, which improved the pain in his back and buttock.
Keywords: Ankylosing spondylitis, Non-Hodgkin's lymphoma, Follicular lymphoma, Inflammatory back pain
Yongbum Kim, M.D., Nayeon Choi, M.S., Ji-Hui Shin, M.S., Sungsin Jo, Ph.D., Bora Nam, M.D., Ph.D., Tae-Hwan Kim, M.D., Ph.D.
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