Review Article

J Rheum Dis 2012; 19(4): 189-195

Published online August 30, 2012

© Korean College of Rheumatology

류마티스관절염의 실험 동물 모델: 방법과 활용

김현옥ㆍ이상일

경상대학교 의학전문대학원 내과학교실, 건강과학연구원

Experimental Animal Models for Rheumatoid Arthritis: Methods and Applications

Hyun-Ok Kim, Sang-Il Lee

Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea

Correspondence to : Sang-Il Lee

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovitis and joint damage. The etiology of RA is multi-factorial including various genetic and environmental factors, and the pathogenesis is complex involving lymphocyte infiltration, synovial cell proliferation, pannus formation, and cartilage and bone destruction. Various animal models have been used to study potential etiopathogenetic mechanisms in RA. They are also extensively used to test new potential therapeutic agents. Despite some limitations, those animal models have significantly progressed our understanding of the basic mechanisms and have contributed to several current major advances in the treatment of RA. These models include the induced arthritis models such as collagen-induced arthritis (CIA), antibody-induced arthritis, the genetically manipulated or spontaneous arthritis models, and humanized mouse models. The choice regarding the proper model should be performed carefully, taking into account the biology of the animal model and the therapeutic target under evaluation in order to make better predictions of efficacy in human RA. Thus, in this review, we describe important mouse models of RA, focusing on the underlying mechanisms, methods, advantages and limitations, and usefulness.

Keywords Rheumatoid arthritis, Animal model

Article

Review Article

J Rheum Dis 2012; 19(4): 189-195

Published online August 30, 2012

Copyright © Korean College of Rheumatology.

류마티스관절염의 실험 동물 모델: 방법과 활용

김현옥ㆍ이상일

경상대학교 의학전문대학원 내과학교실, 건강과학연구원

Experimental Animal Models for Rheumatoid Arthritis: Methods and Applications

Hyun-Ok Kim, Sang-Il Lee

Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea

Correspondence to:Sang-Il Lee

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovitis and joint damage. The etiology of RA is multi-factorial including various genetic and environmental factors, and the pathogenesis is complex involving lymphocyte infiltration, synovial cell proliferation, pannus formation, and cartilage and bone destruction. Various animal models have been used to study potential etiopathogenetic mechanisms in RA. They are also extensively used to test new potential therapeutic agents. Despite some limitations, those animal models have significantly progressed our understanding of the basic mechanisms and have contributed to several current major advances in the treatment of RA. These models include the induced arthritis models such as collagen-induced arthritis (CIA), antibody-induced arthritis, the genetically manipulated or spontaneous arthritis models, and humanized mouse models. The choice regarding the proper model should be performed carefully, taking into account the biology of the animal model and the therapeutic target under evaluation in order to make better predictions of efficacy in human RA. Thus, in this review, we describe important mouse models of RA, focusing on the underlying mechanisms, methods, advantages and limitations, and usefulness.

Keywords: Rheumatoid arthritis, Animal model

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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