J Rheum Dis 2012; 19(4): 189-195
Published online August 30, 2012
© Korean College of Rheumatology
김현옥ㆍ이상일
경상대학교 의학전문대학원 내과학교실, 건강과학연구원
Correspondence to : Sang-Il Lee
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovitis and joint damage. The etiology of RA is multi-factorial including various genetic and environmental factors, and the pathogenesis is complex involving lymphocyte infiltration, synovial cell proliferation, pannus formation, and cartilage and bone destruction. Various animal models have been used to study potential etiopathogenetic mechanisms in RA. They are also extensively used to test new potential therapeutic agents. Despite some limitations, those animal models have significantly progressed our understanding of the basic mechanisms and have contributed to several current major advances in the treatment of RA. These models include the induced arthritis models such as collagen-induced arthritis (CIA), antibody-induced arthritis, the genetically manipulated or spontaneous arthritis models, and humanized mouse models. The choice regarding the proper model should be performed carefully, taking into account the biology of the animal model and the therapeutic target under evaluation in order to make better predictions of efficacy in human RA. Thus, in this review, we describe important mouse models of RA, focusing on the underlying mechanisms, methods, advantages and limitations, and usefulness.
Keywords Rheumatoid arthritis, Animal model
J Rheum Dis 2012; 19(4): 189-195
Published online August 30, 2012
Copyright © Korean College of Rheumatology.
김현옥ㆍ이상일
경상대학교 의학전문대학원 내과학교실, 건강과학연구원
Hyun-Ok Kim, Sang-Il Lee
Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea
Correspondence to:Sang-Il Lee
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovitis and joint damage. The etiology of RA is multi-factorial including various genetic and environmental factors, and the pathogenesis is complex involving lymphocyte infiltration, synovial cell proliferation, pannus formation, and cartilage and bone destruction. Various animal models have been used to study potential etiopathogenetic mechanisms in RA. They are also extensively used to test new potential therapeutic agents. Despite some limitations, those animal models have significantly progressed our understanding of the basic mechanisms and have contributed to several current major advances in the treatment of RA. These models include the induced arthritis models such as collagen-induced arthritis (CIA), antibody-induced arthritis, the genetically manipulated or spontaneous arthritis models, and humanized mouse models. The choice regarding the proper model should be performed carefully, taking into account the biology of the animal model and the therapeutic target under evaluation in order to make better predictions of efficacy in human RA. Thus, in this review, we describe important mouse models of RA, focusing on the underlying mechanisms, methods, advantages and limitations, and usefulness.
Keywords: Rheumatoid arthritis, Animal model
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