Case Report
J Rheum Dis 2012; 19(6): 359-363
Published online December 30, 2012
© Korean College of Rheumatology
류마티스관절염 환자에서 발생한 폐포자충 폐렴 1예
최은영1ㆍ김진옥1ㆍ김영삼1,2ㆍ윤호주1ㆍ전재범1,2ㆍ성윤경1,2
한양대학교 의과대학 내과학교실1, 한양대학교 류마티스병원 류마티스내과2
A Case of Pneumocystis Jirovecii Pneumonia in a Patient with Rheumatoid Arthritis
Correspondence to : Yoon-Kyoung Sung
We report a 67-year-old woman who developed Pneumocystis jirovecii pneumonia (PJP) as a complication of treatment with immunosuppressant, such as methotrexate and leflunomide, for rheumatoid arthritis. She had mild fever and non-productive cough, but there was neither symptoms of dyspnea nor typical X-ray findings at initial presentation. However, rapid progression on a chest X-ray, respiratory symptoms and findings of high-resolution chest computed tomography in a few days suggested a possibility of PJP infection. A polymerase chain reaction-based detection of Pneumocystis jirovecii in induced sputum allowed us an early diagnosis of PJP. Through a preemptive treatment with Trimethoprim-sulfamethoxazole, she fully recovered from PJP.
Keywords Pneumocystis jirovecii, Rheumatoid arthritis, Immunosuppressant
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Case Report
J Rheum Dis 2012; 19(6): 359-363
Published online December 30, 2012
Copyright © Korean College of Rheumatology.
류마티스관절염 환자에서 발생한 폐포자충 폐렴 1예
최은영1ㆍ김진옥1ㆍ김영삼1,2ㆍ윤호주1ㆍ전재범1,2ㆍ성윤경1,2
한양대학교 의과대학 내과학교실1, 한양대학교 류마티스병원 류마티스내과2
A Case of Pneumocystis Jirovecii Pneumonia in a Patient with Rheumatoid Arthritis
Eun-Young Choi1, Jin-Ok Kim1, Young-Sam Kim1,2, Ho-Joo Yoon1, Jae-Bum Jun1,2, Yoon-Kyoung Sung1,2
Department of Internal Medicine, Hanyang University College of Medicine1, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases2, Seoul, Korea
Correspondence to:Yoon-Kyoung Sung
Abstract
We report a 67-year-old woman who developed Pneumocystis jirovecii pneumonia (PJP) as a complication of treatment with immunosuppressant, such as methotrexate and leflunomide, for rheumatoid arthritis. She had mild fever and non-productive cough, but there was neither symptoms of dyspnea nor typical X-ray findings at initial presentation. However, rapid progression on a chest X-ray, respiratory symptoms and findings of high-resolution chest computed tomography in a few days suggested a possibility of PJP infection. A polymerase chain reaction-based detection of Pneumocystis jirovecii in induced sputum allowed us an early diagnosis of PJP. Through a preemptive treatment with Trimethoprim-sulfamethoxazole, she fully recovered from PJP.
Keywords: Pneumocystis jirovecii, Rheumatoid arthritis, Immunosuppressant
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