Case Report
The Journal of the Korean Rheumatism Association 2003; 10(4): 438-441
Published online December 30, 2003
© Korean College of Rheumatology
류마티스 관절염에서 발생한 Cerebral Aspergillosis 1예
이태근·최재훈·최철웅·이상용·이준희·이정욱·김상수·김성일
부산대학교 의과대학 내과학교실
A Case of Cerebral Aspergillosis in a Patients with Rheumatoid Arthritis
Correspondence to : Sung Il Kim
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.
Keywords Rheumatoid arthritis, Invasive Aspergillus, Central nervous system
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Case Report
The Journal of the Korean Rheumatism Association 2003; 10(4): 438-441
Published online December 30, 2003
Copyright © Korean College of Rheumatology.
류마티스 관절염에서 발생한 Cerebral Aspergillosis 1예
이태근·최재훈·최철웅·이상용·이준희·이정욱·김상수·김성일
부산대학교 의과대학 내과학교실
A Case of Cerebral Aspergillosis in a Patients with Rheumatoid Arthritis
Tae Kun Lee, M.D., Jae Hoon Choi, M.D., Cheul Woong Choi, M.D., Sang Yong Lee, M.D., Jun Hee Lee, M.D., Joung Wook Lee, M.D., Sang Soo Kim, M.D., Sung Il Kim, M.D.
Department of Internal Medicine, College of Medicine, Pusan National University,
Correspondence to:Sung Il Kim
Abstract
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.
Keywords: Rheumatoid arthritis, Invasive Aspergillus, Central nervous system
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